Phytochemical investigation of the chloroform extract of Tinospora cordifolia yielded a new clerodane diterpenoid tincordin along with tinosporide, 8-hydroxytinosporide, columbin, 8-hydroxycolumbin and 10-hydroxycolumbin. The structure of the new compound was elucidated comprehensively using 1D and 2D NMR methods. All major clerodane diterpenoids isolated were tested for their efficacy as insect antifeedants against Earias vitella, Plutella xylostella and Spodoptera litura.
A novel series of analogues based on 5-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-4-phenyl-2H-1,2,4-triazole-3(4H)-thione core have been synthesized and their potential as antibacterial, antifungal and antitubercular agents was examined. The structure-activity relationship (SAR) studies of these derivatives 5 (a-k) clearly indicate the vital role of lipophilicity as a major factor in enhancing the biological activity of these compounds. Among the compounds screened, 5a, 5c, 5d, 5j and 5k displayed significant activity against Mycobacterium tuberculosis H37Rv strain.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.