Design, synthesis of some new (2-aminothiazol-4-yl)methylester derivatives as possible antimicrobial and antitubercular agents

Synthesis and Evaluation of Some Novel 2‐Amino‐4‐Aryl Thiazoles for Antitubercular Activity

“…The results (Table ) show that all the compounds exhibited good activity against said strain of microorganism at 1500 μg/mL. The results can be correlated with the antitubercular activity of reported derivatives of thiazole, for example, 4‐methyl‐ N ‐(4–0 × 0–2‐phenylthiazolidin‐3‐yl)‐2‐(pyrazine‐2‐yl)thaizol‐5‐carboxamide (MIC 30 μg/mL) , 2‐aminothazol‐4‐yl)methylester (MIC 1–10 μg/mL) , Thiazole based on t‐3‐alkyl‐r‐2,C‐6‐diarylpiperidin‐4‐one (MIC 265 μg/mL) , Substituted phenyl thiazole derivatives (MIC 100 μg/mL) , S‐derivatives of clubbed triazolyl thiazole (MIC 332 μg/mL) , and N ‐3‐(4‐(chlorophenylthiazol‐2‐yl)‐2‐(amino)methyl)‐quinazoline‐4‐(3 H )‐one (MIC 100 μg/mL) .…”

“…The halogen substituted aromatic substituents at fourth position increases lipophilic nature. In addition, the amino group at second position of thiazole would be essential element for hydrogen bonding . Therefore, the present study was designed to synthesize such scaffold and to evaluate their antitubercular activity.…”

A new route for the synthesis of 4-arylacetamido-2-aminothiazoles and their biological evaluation

“…The 1,3-thiazole nucleus has been a seat of diverse biological activities through its innumerable derivatives [1][2][3][4]. 2,4-and 2,5-disubstituted thiazoles have exhibited promising anti-inflammatory, analgesic and antipyretic activities [5][6][7][8][9].…”

Synthesis and molecular docking studies of a new series of bipyrazol-yl-thiazol-ylidene-hydrazinecarbothioamide derivatives as potential antitubercular agents

“…Eventually, such long term exposure of antibiotics often results in nonconformity to the treatment and results in development of multidrug resistant strains 8 . Thiazole and their derivatives have been steadily evaluated for their diverse biological and pharmaceutical activities as anticancer 28 , antitumor 23,24 , antimalarial 25 , antimicrobial 26 , anti-inflammatory 27 and anti-hypolipidemic 28 agents. Hydrazinecarbothioamides or thiosemicarbazones consist of an imperative class of nitrogen and sulfur containing compounds, and have acknowledged huge attention owing to their notable biological and pharmacological properties, such as antimycobacterial 9 , antioxidant 10,11 , antibacterial 12 , antiviral, antiamoebic, and antitumor 13 , analgesic, anti-inflammatory 14 and antifungal 15 .…”