Multiple endocrine neoplasia type 2A (MEN2A) is a hereditary syndrome associated with tumours of the endocrine system. Principally, it is characterized by medullary thyroid carcinoma (MTC) with some individuals also developing phaeochromocytoma and hyperparathyroidism. Patients with fewer than two clinical features require either an identification of a germline rearranged in transfection mutation, or MEN2A characteristics in first-degree relatives, to establish a diagnosis of MEN2A. We present the case of a 54-year-old female with MEN2A, diagnosed by genetic screening, due to a substantial history of the disease in her ancestry. This case outlines the successful treatment of recurrent phaeochromocytoma, through the medium of radioactive iobenguane as an adjunct to surgical management. The report focuses particularly on the significance of innovative treatment strategies and forthcoming approaches to improve patient care in treating phaeochromocytoma in MEN2A.
Context:
Sonoelastography is an emerging noninvasive imaging modality used for the assessment of soft tissue lesions. Parotid and submandibular glands are relatively superficial structures which can be easily assessed and examined to characterize the lesions.
Aim:
The aim of the present study is to evaluate the sonoelastographic features of various benign and malignant parotid and submandibular gland lesions, and correlate their findings with pathology.
Materials and Methods:
In a prospective observational study conducted in Acharya Vinoba Bhave Rural Hospital of JNMC College, Sawangi, Wardha, 24 patients who presented with salivary gland lesions were evaluated with sonoelastography during 2 years.
Results:
The most common age group in this study was 51–60 years, followed by 31–40 years. Benign lesions were more common than malignant ones. Higher values of strain ratio were seen in cases of malignant tumours correlating well with score of 3 and 4 on elastography.
Conclusions:
Sonoelastography is a recent advance in ultrasound for the evaluation of salivary gland lesions showing good correlation with pathology so it can be employed routinely in presurgical evaluation.
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