HighlightsPentavalent reassortant rotavirus vaccine was tested for efficacy in infants.The vaccine (BRV-PV) showed excellent tolerability and a good safety profile.Primary analysis efficacy was 36% against SRVGE and up to 60.5% against VSRVGE.The efficacy through 2 years of age was 39.5% (SRVGE) and 54.7% (VSRVGE).The intent to treat analyses confirmed all the per protocol analyses.

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Background: Backache is a national, personal and clinical problem. It is experienced by most of the population at some time and is a drain on the nation’s resources. Personally, it is distressing because it can remain a major unresolved dilemma and clinically it poses challenges in diagnosis and treatment.Methods: The present cross sectional study was conducted among 200 patients presenting with chronic low back pain, in the OPD of Post Graduate Department of Orthopaedics, Govt. Medical College, Jammu over a period of one year from November 2006 to October 2007.Results: The average age of patients was 38.39 years with slight male predominance. Majority of the patients were non-sedentary workers. In majority of the cases (58%), duration of low backache was from 3 months to 1 year with the average of 25.8 months (2.158 years). The commonest mode of presentation was low back pain with radiation to lower limbs. Seasonal variation in the intensity of pain was observed in 50% of the cases. Tenderness of the spine was the commonest physical sign. Disc degenerative disease was found to be commonest cause of low backache, being present in 72% of the cases.Conclusions: Low back pain is common in 3rd and 4th decade of life. The commonest mode of presentation was low back pain with radiation to lower limbs. Disc degenerative disease was found to be commonest cause of low backache, being present in 72% of the cases.

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INTRODUCTIONIn India, breast carcinoma is the second most common malignant neoplasm next to cervical cancer in females. 1 It is the leading cause of morbidity and mortality. 2 Regarding breast pathology, palpable breast lump is most common presentation of patients. Fine needle aspiration cytology (FNAC), mammography and ultrasonography along with clinical examination (triple test) have become the standard approach to the investigation of palpable breast lumps.3 FNAC is rapid, simple, safe, costeffective and good screening procedure with high sensitivity, specificity and hence overall diagnostic accuracy. 4,5 The main purpose of FNAC in breast lumps is to pick all the suspicious breast lesions and do categorization accordingly, as in most cases definitive treatment can often be based on cytological diagnosis without the need for histopatholgical ABSTRACT Background: Fine-needle aspiration cytology (FNAC) has proved to be a rapid, safe, cost effective and good screening or initial diagnostic tool for early diagnosis and management of palpable breast swellings. The present study was conducted to describe and categorize various breast lesions on FNAC. The study also aimed to find out the diagnostic accuracy of FNAC procedure. Methods: This study was carried out on 175 patients who presented with palpable breast swellings in Government Hospital Gandhi Nagar, Jammu, Jammu and Kashmir, India and subsequently referred to Pathology Department of Govt. Hospital Gandhi Nagar over a period of two years and eight months from January 2013 to September 2015. Lesions were categorized as per cytomorphological features obtained on FNAC. Histopathological correlation was done on 68 cases inclusive of all malignant cases. Results: 156 (89%) cases were categorized as benign and 19 cases (11%) as malignant on FNAC out of 175 cases. The most common benign lesion was fibro adenoma (41%) and the most common breast carcinoma was ductal carcinoma (65%). Sensitivity, specificity, positive predictive value, negative predictive value, LR+ and LR-came out to be 85%, 95.8%, 89%, 93.8%, 20.4 and 0.15 respectively. Conclusions: FNAC is a good screening procedure for initial diagnosis of breast lumps. It is highly useful procedure in secondary care centres due to its cost effectiveness, rapid and safe nature.

Background: Hand injuries are very common in this industrialized world. Significant number of patients report every day to the emergency department with various patterns of hand injuries. It is important to understand these patterns in order to plan proper management and develop safety protocols aimed at preventing these injuries.Methods: The present cross sectional study was conducted among 150 patients presenting with Open hand injuries, in the OPD and emergency of Post Graduate Department of Orthopaedics, Government Medical College, Jammu over a period of one year from January 2010 to December 2010.Results: Out of 150 cases 131(87.33%) were males and 19 (12.67%) were females. The commonest age group affected was 21-30 years (34%) followed by 11-20 years (23%). Maximum injuries 90 (60%) occurred in the time interval from 4 pm to midnight. Majority of patients 67 (45%) sustained injury while at work.  Occupation-wise 37 (25%) patients were unskilled workers, mainly laborers, 35 (23%) were farmers, while the remainder belonged to various other professions. In this series machine injuries, assault and road traffic accidents accounted for most injuries, representing 61 (41%), 25 (17%) and 16 (11%) patients respectively. Traumatic amputation (30%) was the most common injury. The index (21%) and middle (21%) fingers were involved more commonly. Tendon injuries (31%) were more frequent than compound fractures (23%).  Conclusions: Hand trauma predominantly affects young males who have occupational exposure to different machines. A proper understanding of the pattern of injury will help in better management.