Malaria is a chronic disease having large prevalence in tropical and subtropical countries. CD35 protein density on RBCs determines susceptibility to P. falciparum infection. In our population, complement receptor Type-1 (CD35) gene polymorphism determine the density of CD35 protein on RBCs. As we know, CD35 protein is an adhesion protein for P. falciparum and high density confer chances to infection. Polymorphism of CR1 (CD35) gene, SNP Intron 27 (T520C) in our population reveals three genotypes HH, HL and LL. Genotype HL (P=0.0298*) frequent distributed in population and showing association between case and control. In our population LL genotype have protective effect for P. falciparum infection whereas HH, and HL genotype confer high density of CD35 protein on RBCs surface. The frequency of H allele (in case=65.47%, control=55.38%) is high in comparison to L alleles (in case =34.52%, control = 44.61%). Frequency of H and L allele (P= 0.0241*) significantly associated but not carriage rate (P=0.2127) between case and control population. Elevated TNF-α level in blood serum reveals quantity of infection level and having strong association (P<0.0001 ***) with P. falciparum malarial infection.
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