Background/aim. Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2. Although the main symptoms of this virus are in the respiratory system, neurological clinical manifestations in the form of the central nervous system (CNS), peripheral nervous system (PNS) and musculoskeletal system are often found. This study aims for data on the characteristics of neurological manifestations in COVID-19 patients. Research methods. A retrospective cohort study with medical record from June 2020 to June 2021 which was analyzed descriptive, Chi-Square test and survival using SPSS program. Research result. There were 136 patients with PCR swab results (+), 80 (58.8%) male and 56 (41.2%) female, age > 50 years 92 (67.6%), 47 (34.6%) died. Neurological manifestations in the CNS that stroke 72 (52.9%) RR 4.8 (CI 95% 2.1-10.6; p<0.001), seizures 19 (14%) RR 14.7 (95% CI 4-54.3; p <0.001), headache 32 (23.5%) RR 5.7 (95% CI 2, 4-13.4; p<0.001), encephalopathy 35 (25.7%) RR 41.1 (95% CI 12.7-132.7; p<0.001), in the PNS myasthenic crisis 6 (4.4%) RR 10.4 (95% CI 1.2-92.5; p = 0.035) anosmia 73 (53.7%) RR 0.2 (95% CI 0.1-0.5; p<0.001) while musculoskeletal myalgia 25 (18.4%) and low back pain 18 (13.2%) was not significant. Conclusion. Most neurological clinical manifestations in the CNS (stroke, headache, seizures and encephalopathy) followed by the PNS (myasthenia crisis and anosmia). Neuroinvasive complications are thought to play a role as one of the causes of respiratory failure and death in patients with COVID-19.
Introduction. Gastrointestinal (GI) bleeding is a serious complication of stroke causing high morbidity. Atrial fibrillation is associated with both ischemic stroke and GI bleeding due to usage of anticoagulant. The aim of this study is to determine the risk factors of GI bleeding in ischemic stroke patients with atrial fibrillation. Material and methods. All ischemic stroke patients with atrial fibrillation from January 2017 to December 2018 were extracted from our hospital-based stroke registry. We extracted demographical characteristic, subtypes of stroke, and medication history. Results. We found 96 ischemic stroke patients with AF were included in the study. Dyslipidemia (RR: 0.2; 95%CI: 0.043-0.939; p = 0.049) and antihyperlipidemic drugs (RR: 0.183; 95%CI: 0.039-0.857; p = 0.022) was associated with lower GI bleeding risk. There were no significant association between other risk factors and GI bleeding incidence Conclusion. Our research shows that dyslipidemia and history of antihyperlipidemic drugs are associated with lower GI bleeding risk in ischemic stroke patients with AF.
Stroke merupakan salah satu penyakit penyebab kematian tertinggi di Indonesia, hingga saat ini belum ada pengobatan yang dapat menyembuhkan penyakit stroke. Telah banyak penelitian yang membahas mengenai pencegahan terjadinya stroke, namun belum banyak yang membahas mengenai pengobatan untuk menyembuhkan stroke. Dewasa ini terapi dengan sel punca telah banyak dipergunakan untuk berbagai penyakit yang belum dapat disembuhkan dengan obat-obatan modern salah satunya stroke. Untuk itu penulis ingin mengangkat tema terapi sel punca terhadap penyakit stroke.
Kata Kunci: Sel Punca, Stroke Iskemik, Stem Cell, Pencegahan Stroke Sekunder
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.