The main signs of Alzheimer's disease (AD) are cognitive impairment and senile plaques composed of amyloid beta (A) observed in patients' brains. Therefore, therapy for AD focuses on the removal of A. We developed an ''edible vaccine'' that employs intestinal immunity with little to no side effects. Rice was utilized as an edible vaccine. It expressed GFP-A42. A rice was administered orally to wild-type (WT) mice causing production of anti-A antibodies. Since A rice was mixed with the cholera toxin B subunit (CTB), antibody against the rice seed protein was also produced. Then, mice were caused to develop immune tolerance against the rice seed protein by oral administration of A rice mixed with CTB. The results indicated that only anti-A antibodies were produced.
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