Mediastinal lymphoma is a rare tumor. Approximately 10% of primary mediastinal lymphoma occur in mediastinum. In this study we look for sex and age characteristics, histopathology and immunohistochemical profile of mediastinal lymphoma. Data were collected from the Anatomical Pathology laboratory Dr. Soetomo archives from January 2016 to August 2018. Seventeen cases of mediastinal lymphoma were found predominantly in males (76.47 %). The age range was between 17 and 64 years old. Distribution of tumor type was as follows: Non-Hodgkin’s Lymphoma, B-cell type high grade (Ki67 > 30%) 17.65 % and Non-Hodgkin’s Lymphoma, B-cell type low grade (Ki67 <30%) 11.76%, Non-Hodgkin’s Lymphoma, T-cell type high grade 11.76%, Non-Hodgkin’s Lymphoma unknown subtype 35.29%, Classical Hodgkin’s Lymphoma (CHL) 17.65%, T-cell Lymphoblastic Lymphoma (T-LBL) 5.88%. Histologically, Non-Hodgkin’s Lymphoma showed a diffuse pattern consisting of anaplastic lymphoid cells, pleomorphic nuclei, coarse chromatin, thin cytoplasm between fibrotic stroma and the immunohistochemistry profile showed positive for CD20 in NHL B-cell type. CD3 were positive in Peripheral T-cell Lymphoma and T-Lymphoblastic Lymphoma (T-LBL). Classical Hodgkin’s Lymphoma showed large cells (reed-stenberg cells) and Hodgkin’s cells dispersed between an inflammatory background, CD30 were positive in CHL cases. Tdt was positive in T-LBL cases.
One of the prognosis factors of colorectal adenocarcinoma is histopathological grading. The expression of programmed death-ligand (PD-L1) and cyclin D1 has the potential to become one of the predictive and prognostic factors for tumor cells in colorectal cancer. This study aimed to identify the relationship between the expression of PD-L1 and cyclin D1 and histopathological grading in colorectal adenocarcinoma. It is an analytic observational study with a cross-sectional approach using a sample of 34 paraffin blocks of colorectal adenocarcinoma preparations at the Anatomical Pathology Laboratory, RSUD Dr. Soetomo Surabaya for the period January 2016 to December 2020. The parameter of the assessment was the percentage of PD-L1 and cyclin D1 antibodies that were positively stained on the membrane and nucleus of tumor cells which was subjected to histopathological grading assessment based on hematoxylin-eosin (HE) staining. The data were analyzed using Spearman’s correlation. PD-L1 expression was positively correlated with histopathological grading in colorectal adenocarcinoma (p=0.006). Cyclin D1 expression did not correlate with histopathological grading in colorectal adenocarcinoma (p=0.891). Statistical analysis showed no significant correlation between PD-L1 and cyclin D1 expressions (r = 0.188; p = 0.286).
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