correlation of the expression of PD-L1 and Cyclin and Histopathological Grading in Colorectal Adenocarcinoma

Abstract

One of the prognosis factors of colorectal adenocarcinoma is histopathological grading. The expression of programmed death-ligand (PD-L1) and cyclin D1 has the potential to become one of the predictive and prognostic factors for tumor cells in colorectal cancer. This study aimed to identify the relationship between the expression of PD-L1 and cyclin D1 and histopathological grading in colorectal adenocarcinoma. It is an analytic observational study with a cross-sectional approach using a sample of 34 paraffin blocks of colorectal adenocarcinoma preparations at the Anatomical Pathology Laboratory, RSUD Dr. Soetomo Surabaya for the period January 2016 to December 2020. The parameter of the assessment was the percentage of PD-L1 and cyclin D1 antibodies that were positively stained on the membrane and nucleus of tumor cells which was subjected to histopathological grading assessment based on hematoxylin-eosin (HE) staining. The data were analyzed using Spearman’s correlation. PD-L1 expression was positively correlated with histopathological grading in colorectal adenocarcinoma (p=0.006). Cyclin D1 expression did not correlate with histopathological grading in colorectal adenocarcinoma (p=0.891). Statistical analysis showed no significant correlation between PD-L1 and cyclin D1 expressions (r = 0.188; p = 0.286).