Breast cancer is one of the most common cancer in the world that occurs in women. Thedevelopment process of cancer is regulated by a variety of pathways that involve various enzymes. COX-2 is an enzyme involved in the inflammatory process in further stages that will play importantroles in breast cancer cells progression. The uses of natural compound from plants give new hope forbreast cancer treatment with minimal side effects. Temulawak is a potential breast cancer drugs because it contains curcuminoid and xanthorizol. Curcumin and xanthorizol has been reported to have chemopreventive effect on colon cancer development. The drug that has same functions of these compounds needed to be examined with various approaches. One of the approach used in this research is molecular docking. Based on ligand analysis with Lipinski and toxicity test using ADMET, curcuminoid and xanthorizol met criteria as medicinal compounds. Curcumin had the highest binding affinity(?G) with the value -9.3 kcal/mol but still under commercial drug celecoxib binding affinity (?G) = -12,5. There were three hydrogen bonds in amino acid Arg106 and Tyr341 His75 which were amino acids in the active side of COX-2. There were 15 amino acids that have similar ties with commercial drug celecoxib. Based on the binding affinity and binding similiarity, curcuminoid and xanthorizol were predicted as compounds that have potential as competitive inhibitor of COX-2 enzyme.
Pemeriksaan skrining penularan tuberkulosis pada anggota keluarga tinggal serumah adalah merupakan upaya untuk meningkatkan penemuan kasus tuberkulosis dan merupakan hal yang penting dalam pengendalian tuberkulosis. Angka kejadian TB Positif di Balai Besar Kesehatan Paru Masyarakat (BBKPM) Makassar pertahunnya mengalami kecenderungan meningkat sehingga resiko penularan akan bertambah terutama terhadap anggota keluarga karena penularan TB melalui droplet infection. Kegiatan pengabdian masyarakat ini untuk meningkatkan kapasitas tenaga kesehatan dalam upaya penanggulangan penyakit tuberkulosis dengan meningkatkan kemampuan deteksi dini penularan penyakit tuberkulosis pada anggota keluarga kontak serumah. Metode pada pengabdian ini dengan melakukan uji Tuberkulin pada keluarga kontak serumah penderita TB aktif di BBKPMM. Kegiatan ini dilakukan bulan Juli sampai dengan Oktober tahun 2019. Diagnosis pemeriksaan dilakukan oleh perawat dan Analis Tenaga Laboratorium Medis. Anggota keluarga pasien yang dijadikan peserta dalam kegiatan ini adalah keluarga penderita TB aktif yang ada di ruang perawatan inap lantai II di BBKPMM. Hasil pemeriksaan uji tuberkulian dari 45 anggota keluarga kontak serumah penderita TB paru aktif diperoleh 22 orang (49%) yang positif dan 23 orang (51%). Hasil kegiatan ini menjadi masukan bagi pihak BBPKMM akan melakukan tindak lanjut bagi anggota keluarga penderita yang positif.
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