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Professor Zanchetti died during the development of these Guidelines, in March 2018. He contributed fully to the redaction of these Guidelines, as a member of the Guidelines' Task Force and as a section coordinator. He will be sadly missed by colleagues and friends.

Obaj przewodniczący przyczynili się w jednakowym stopniu do powstania niniejszego dokumentu. Recenzentów dokumentu z ramienia Komisji ESC ds. Wytycznych Postępowania (CPG) oraz z ramienia ESH, jak również ze strony narodowych towarzystw kardiologicznych wchodzących w skład ESC oraz narodowych towarzystw nadciśnienia tętniczego wchodzących w skład ESH wymieniono w Dodatku.

†Professor Zanchetti died during the development of these Guidelines, in March 2018. He contributed fully to the redaction of these Guidelines, as a member of the Guidelines' Task Force and as a section coordinator. He will be sadly missed by colleagues and friends.

Postnatal depression is a serious mental health problem that may be reduced by exercise. AimThis study examined the feasibility of an exercise intervention for women with postnatal depression, and assessed which methods of recruitment are most effective. Design of studyRandomised controlled trial. SettingGeneral practice and the community. MethodParticipants were recruited from various sources and randomised to an exercise intervention or usual care with follow-up at 12 weeks. As well as assessing feasibility, other trial outcomes included exercise participation and self-efficacy for exercise. Levels of depression were assessed but the study was not powered to show a difference in this. ResultsThe recruitment rate of eligible patients was 23.1%. The highest recruitment rate was via referral from the psychiatric mother and baby unit (9/28; 32.1%), followed by invitation letters from GPs (24/93; 25.8%). Thirty-eight eligible participants were randomised. At follow-up there was no significant difference in exercise participation between groups. The intervention group reported significantly higher selfefficacy for exercise compared to usual care, but depression scores did not differ. ConclusionExercise participation over the 12-week period was not significantly increased, possibly because it is difficult to motivate women with postnatal depression to exercise, or the intervention was not sufficiently intensive. Eligible patients were recruited into this study but response rates were low. Optimum methods of recruitment in this difficult-to-reach population are required prior to a substantive trial. Further research is imperative given poorly-evidenced recommendations by the National Institute for Health and Clinical Excellence to consider this treatment.

Background Cardiovascular disease continues to cause significant morbidity, mortality, and impaired quality of life, with unrealized health gains from the underuse of available evidence. The Transitions, Risks, and Actions in Coronary Events Center for Outcomes Research and Education (TRACE-CORE) aims to advance the science of acute coronary syndromes (ACS) by examining the determinants and outcomes of the quality of the transition from the hospital to the community and by quantifying the impact of potentially-modifiable characteristics associated with decreased quality of life, rehospitalization, and mortality. Methods and Results TRACE-CORE is composed of a longitudinal multi-racial cohort of patients hospitalized with ACS, two research projects, and development of a nucleus of early stage investigators. We are currently enrolling 2,500 adults hospitalized for ACS at 6 hospitals in the northeastern and southeastern United States. We will follow these patients for 24 months after hospitalization through medical record abstraction and six patient interviews focusing on quality of life, cardiac events, rehospitalizations, mortality, and medical, behavioral, and psychosocial characteristics. The Transitions Project studies determinants of and disparities in outcomes of the quality of patients’ transition from the hospital to the community. Focusing on potentially modifiable factors, the Action Scores Project will develop and validate action scores to predict recurrent cardiac events, death, and quality of life, describe longitudinal variation in these scores, and develop a dashboard for patient and provider action based on these scores. Conclusions In TRACE-CORE, sound methodologic principles of observational studies converge with outcomes and effectiveness research approaches. We expect that our data, research infrastructure, and research projects will inform the development of novel secondary prevention approaches and underpin the careers of CVD outcomes researchers.

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The GRACE Risk Score is a well-validated tool for estimating short- and long-term risk in acute coronary syndromes (ACS). GRACE Risk Score 2.0 substitutes several variables that may be unavailable to clinicians and thus limit use of the GRACE Risk Score. GRACE Risk Score 2.0 performed well in the original GRACE cohort. We sought to validate its performance in a contemporary multiracial ACS cohort, in particular among black ACS patients. We evaluated the performance of the GRACE Risk Score 2.0 simplified algorithm for predicting 1-year mortality among 2,131 participants in TRACE-CORE, a multiracial cohort of patients discharged alive after an ACS in 2011–2013 from 6 hospitals in Massachusetts and Georgia. The median age of study participants was 61 years, 67% were men, and 16% were black. Half (51%) of the patients experienced a non–ST-segment elevation myocardial infarction (NSTEMI) and 18% an ST-segment elevation myocardial infarction (STEMI). Eighty (3.8%) patients died within 12 months of discharge. The GRACE Risk Score 2.0 simplified algorithm demonstrated excellent model discrimination for predicting 1-year mortality following hospital discharge in the TRACE-CORE cohort (c-index = 0.77). The c-index was 0.94 among patients with STEMI, 0.78 among patients with NSTEMI, and 0.87 among black ACS patients. In conclusion, the GRACE Risk Score 2.0 simplified algorithm for predicting 1-year mortality exhibited excellent model discrimination across the spectrum of ACS types and racial/ethnic subgroups and thus may be a helpful tool to guide routine clinical care for ACS patients.