The solubility of certain solids was increased markedly in supercritical carbon dioxide by adding small amounts of various cosolvents. For 2-aminobenzoic acid, the addition of only 3.5 mol % methanol increased the solubility 620%. By use of a modified van der Waals equation of state, over 15 new solubility isotherms were correlated within 7% and were predicted qualitatively by calculating the attraction constants using dispersion, orientation, acidic, and basic solubility parameters. These binary supercritical solvents can be highly selective for particular solutes due to specific types of intermolecular interactions.
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