The study findings emphasize the importance of relationship-oriented experiences as part of assessment and intervention strategies for individuals with depression.
Neurotrophic factors support the differentiation and survival of neurons and influence properties of synaptic transmission. The neurotrophic hypothesis postulates a retrograde action of trophic factors: their production and release by target cells and their uptake by innervating axons. Besides the retrograde route of trophic messengers, the survival of neurons and the development of synapses is thought to be also regulated by anterograde, afferent trophic signals. We now show that exogenous neurotrophins are transported in the anterograde direction, from cell bodies to the axon terminals, and that the intact neurotrophin is released after anterograde transport, taken up and utilized by second-order visual neurons in the developing chick brain. These results suggest that anterogradely transported neurotrophins may play a role in synaptic plasticity and may have effects at more than one synapse beyond the initial release site.
We thank Dr. Ronal d Li ndsay (Regeneron, Tarrytown, NY) for the gift of BDNF and NT-3, and Drs. Hi deaki Tanaka and Gisela Weskamp for the gift of ~75 antibodies. Basic FGF was kindly provi ded by Chi ron Corporation. We also thank Drs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.