SPECIES DIFFERENCES I N I 7-HYDROXYCORTICOSTEROIDS
7injection, the solubilizer used and the handling of the animals, particularly after irradiation, were not involved in either the rate of mortality or the total mortality because if they had been, definite differences in both of these factors would have shown up in the pre-and post-irradiation methylglucamine groups. The non-irradiated control groups and the salinemethylglucamine and flavonoid injected control groups had no deaths during the experimental period or at any time thereafter up to 60 days. This indicates that the deaths obtained in the medicated irradiated groups were not due to the flavonoids themselves.
Discussion.The results herein reported concerning the ineffectiveness of parenterally administered rutin, hesperidin, hesperidin methyl chalcone, and naringin in modifying Roentgen ray irradiation mortality in guinea pigs confirm the observations of Dauer and Coon ( 10) who gave rutin, hesperidin methyl chalcone, and citrus vitamin P by the oral route. The results of previous investigators (2,4,7,10) as well as our own would definitely indicate that the flavonoids are incapable of modifying the radiation syndrome in mice, rats, guinea pigs, or dogs.
Summary.It has been shown that rutin, hesperidin, hesperidin methylchalcone, and naringin were ineffective in modifying Roent-gen ray irradiation lethality in guinea pigs. There was an indication that post-irradiation medication with rutin may have increased the rate of mortality.
An epidemic of gastroenteritis during which an unusually high incidence of hypertonic dehydration was encountered in infants is reported.
Analysis of the feedings received by the infants during the initial phase of diarrhea indicates that those who developed hypernatremia had received feedings in which the ratio of solutes to water was higher than that in the estimated continuing losses of fluid through stools, urine, and skin and lungs.
Considerations to be employed in the prevention and treatment of hypernatremia and dehydration during diarrhea are discussed.
The physician must develop his clinical judgment in determining when parenteral rather than oral therapy is required in diarrhea—and not depend on a routine regimen or solution for oral therapy.
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