Imidazo[1,2-a]pyridine is one of the most potential bicyclic 5-6 heterocyclic rings that is recognized as a "drug prejudice" scaffold due to its broad range of applications in medicinal chemistry such as anticancer, antimycobacterial, antileishmanial, anticonvulsant, antimicrobial, antiviral, antidiabetic, proton pump inhibitor, insecticidal activities. This scaffold has also been represented in various marketed preparations such as zolimidine, zolpidem, alpidem. Therefore, several attempts were made to carry out the structural modifications of this scaffold to discover and develop novel therapeutic agents. This review provides a valuable insight into the research findings of wide range of derivatives of imidazo[1,2-a]pyridine scaffold leading to promising heterocyclic compounds which could be explored further for the synthesis of new derivatives as well as construction of potential drug-like chemical libraries for biological screening in search of new therapeutic agents.
Isoindole derivatives constitute an important class of biologically active heterocyclic compounds and continue to attract considerable attention due to their diverse pharmacological profile such as, antimicrobial, anthelmintic, insecticidal, cyclooxygenase isoenzyme (COX-2) and thrombin inhibition with special emphasis on anticancer activity. This review highlights anticancer properties of isoindole derivatives and its related structures and hoping that it would further help in generation of new concepts towards rational design and development of more potent and less toxic anticancer agents.
Cytotoxic Activity of 3-(5-Phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-Oxo-4H-chromene-3-carbothioic Acid N-Phenylamides. -A series of chromanyl-1,2,4-dithiazoles (I) and N-phenylthioamides (II) respectively is completed using an earlier described synthetic pathway. All compounds are evaluated for their cytotoxic activity against different human cancer cell lines. (Ia) and (Ib) show maximum cytotoxic activity on neuroblastoma whereas (Ic) has cytotoxic activity on ovarian cancer cell line. -(RAJ, T.; BHATIA, R. K.; KAPUR, A.; SHARMA, M.; SAXENA, A. K.; ISHAR*, M. P. S.; Eur. J. Med. Chem. 45 (2010) 2, 790-794; Bio-org. Photochem. Lab., Dep. Pharm. Sci., Guru Nanak Dev Univ., Amritsar 143 005, India; Eng.) -H. Haber
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