Imidazo[1,2-a]pyridine Scaffold as Prospective Therapeutic Agents

Abstract

Imidazo[1,2-a]pyridine is one of the most potential bicyclic 5-6 heterocyclic rings that is recognized as a "drug prejudice" scaffold due to its broad range of applications in medicinal chemistry such as anticancer, antimycobacterial, antileishmanial, anticonvulsant, antimicrobial, antiviral, antidiabetic, proton pump inhibitor, insecticidal activities. This scaffold has also been represented in various marketed preparations such as zolimidine, zolpidem, alpidem. Therefore, several attempts were made to carry out the structural modifications of this scaffold to discover and develop novel therapeutic agents. This review provides a valuable insight into the research findings of wide range of derivatives of imidazo[1,2-a]pyridine scaffold leading to promising heterocyclic compounds which could be explored further for the synthesis of new derivatives as well as construction of potential drug-like chemical libraries for biological screening in search of new therapeutic agents.

A review on the physiological and pathophysiological role of endothelial glycocalyx

“…The unique loss of heparan sulfates was correlated with the degradation of the glycocalyx and the activation of heparanase TNF‐α‐heparan‐specific sulfate glucuronidase. [ 56,57 ]…”

Crystal structure, Hirshfeld surface analysis and contact enrichment ratios of 1-(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)-2-(1,3-dithiolan-2-ylidene)ethanone monohydrate

“…Compounds with the imidazo[1,2-a]pyridine scaffold exhibit a plethora of biological activities, including acting as receptor ligands, anti-infectious agents, enzyme inhibitors etc. as well as being potential nitrogen heterobicycle therapeutic agents, as described by recent studies (Goel et al, 2016;Deep et al, 2017;Kuthyala et al, 2018). On the other hand, compounds containing the 1,3-dithiolan-2-ylidene moiety have been found to exhibit valuable pharmacological activities, including use as potent broad-spectrum fungicides (Tanaka et al, 1976, Wang et al, 1994, antitumor agents (Huang et al, 2009), potent cephalosporinase inhibitors (Ohya et al, 1982) and anti-HIV agents (Nguyen-Ba et al, 1999;Besra et al, 2005).…”

Imidazo[1,2-a]pyridine A3-Coupling Catalyzed by a Cu/SiO2 Material

“…5,6 Some of them are well-known commercialized drugs with sedative, anti-hypnotic and anti-psychotic effects, such as Alpidem, Zolpidem and Olprinone. 7 Recent investigations showed that imidazo [1,2-a]pyridines are promising drug candidates in cancer treatment. 8,9 The photophysical properties of these heterocyclic scaffolds have also been investigated [10][11][12] and their potential as fluorescent probes 13 and fluorescent metal sensors has been explored.…”