Adenosine stress CT can identify stress-induced myocardial perfusion defects with diagnostic accuracy comparable to SPECT, with similar radiation dose and with the advantage of providing information on coronary stenosis.

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In this study, we evaluated patients with pulmonary arterial hypertension (PAH) and impaired right ventricular function. We used cardiac MRI for the detection of myocardial delayed enhancement (MDE) and its possible association with other clinical variables. 20 patients (6 males and 14 females, aged 44.5+/-11 years; 15 New York Heart Association class III, 5 class IV) with known PAH (13 idiopathic, 7 resulting from chronic pulmonary embolism) were evaluated for the detection of MDE. Short-axis cine images of the heart were made for ventricular function assessment using a steady-state free precession sequence. For MDE evaluation, a short-axis phase-sensitive inversion recovery sequence was performed 10 min after intravenous administration of 0.2 mmol kg(-1) gadodiamide. Right ventricle (RV) systolic dysfunction, RV enlargement and RV hypertrophy were present in 20 patients (RV ejection fraction, 21.5+/-7.2%; RV diastolic diameter, 5.97+/-0.79 cm; RV wall thickness, 0.73+/-0.10 cm). 13 of the 20 patients (65%) were positive for MDE (10 anterior, 12 inferior). All 13 positive patients with MDE demonstrated small hyperintense areas at the insertion points of the RV free wall in the interventricular septum. We found no significant correlation between MDE and ejection fraction or other haemodynamic variables. In this study, MDE correlated positively only with the duration of disease. We found that septal MDE can be present in patients with PAH and impaired ventricular function. However, further studies are necessary to investigate this possible association and its prognostic implication.

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A 16-year-old girl from an area in Brazil where tuberculosis was endemic was admitted because of recurrent chest pain, progressive dyspnea with exertion, and inability to climb more than 1 flight of stairs. She described fatigue, weight loss, night sweats, and adenopathy of her right axilla and neck during the previous 3 months. On admission she looked distressed, with a heart rate of 76 bpm and blood pressure of 110/55 mm Hg. The ECG demonstrated sinus rhythm with first-degree heart block ( Figure 1).Her admission chest radiograph demonstrated cardiomegaly with pulmonary edema (Figure 2). Her cardiac enzymes were negative. The patient underwent cardiac evaluation with 2-dimensional echocardiography (not shown), which revealed an interatrial septal mass, mild tricuspid regurgitation, preserved systolic function, and moderate pericardial effusion.For further characterization of the mass, cardiovascular magnetic resonance imaging (MRI) was performed. Coronal black-blood T2-Turbo Spin Echo and T2-Short T1/Tau Inversion Recovery images of the chest showed adenopathy of the right axilla and a multicystic mass located on the posterior mediastinum (Figure 3). Four-chamber view cine-MRI demonstrated mitral and tricuspid regurgitation, pericardial effusion, and an interatrial septum mass (Figure 4A and 4B). A large retrocardiac pulsatile lesion involving the distal thoracic aorta was also noted (Figure 4 and Movie I of the online-only Data Supplement). Delayed-enhancement MRI confirmed the rounded interatrial septal mass with no evidence of enhancement, consistent with a hematoma of the interatrial septum ( Figure 4C), possibly secondary to a leaking aortic root pseudoaneurysm ( Figure 5B and Movie II of the online-only Data Supplement).Time-resolved contrast-enhanced 3-dimensional magnetic resonance angiography demonstrated multiple pseudoaneurysms extensively distributed throughout the ascending and descending thoracic aorta. Longitudinal aorta and 4-chamber views further depicted partially thrombosed pseudoaneurysms, extensive thickening, and late enhancement of the thoracic aortic wall ( Figures 4C and 5), indicating a likely inflammatory cause.Excisional biopsy of her palpable cervical node was performed after her purified protein derivative test proved to be highly reactive (18 mm). The biopsy results demonstrated caseous and noncaseous necrotizing granulomas with positive culture for acid-fast bacilli ( Figure 6).The patient was given an antitubercular 4-medication regimen. Planned surgical intervention decision was precluded when the patient experienced sudden hypovolemic