Enzootic intranasal adenocarcinoma (ENA) of goats are contagious tumoral disease that characterized occurrence of tumoral masses in nasal cavity of the animals. The etiological agent of the disease is retrovirus and the disease cause high economical loses in goat industry. Retroviruses, respectively inducing lung or nasal adenocarcinomas. The true economic impact of ENA is not known because affected animals are given insights from the herd before actual diagnosis, and suspected disease incidence is rarely reported. Telomerase regulates the proliferative capacity of cells and this enzyme has critical role in tumor progression. The aim of this study is to evaluate telomerase activity in serum and tumoral tissue in goat with ENA. For this aim 11 goat's serum were analyses for telomerase activity. Tumoral tissue sections of totally 14 death goats were examined by immunohistochemically for telomerase expression. In addition, 10 normal goat's serum and nasal tissues that belong slaughtered healthy animals used as control. This study showed that increased serum and tissue telomerase activity in goats with ENA comparing to controls. Also our results showed that telomerase activity becomes a useful prediction marker for tumor development in infected but clinically healthy goats in infected flocks.
In this study it was aimed to determine serum amyloid A, haptoglobin and especially hepcidin concentrations in animals with dual (Bovine viral diarrhea virus / Bovine herpesvirus-1) and single infections (Bovine viral diarrhea virus or Bovine herpesvirus-1) and reference ranges of hepcidin in healthy clinicaly cattle. Previously, studies have been conducted on only hepcidin gene but hepcidin values has not been studied in cattle diseases. In this study totaly 56 cattle were used. In 17 of them Bovine herpesvirus-1, 13 of them Bovine viral diarrhea virus, 4 of them both Bovine herpesvirus-1 and Bovine viral diarrhea virus were diagnosed. The control group was composed of 22 clinicaly healthy animals. According to the results animals naturally infected with dual infection did not show more significant differences level of acute phase proteins compared to animals with single infection. Serum hepcidin values were not differ between the 3 trial groups. But there were significant differences in three trial groups results when compared with control group (P<0.001). Results of haptoglobin analysis were similar to the results of hepcidin analysis. We demonstrated the normal ranges of hepcidin in 22 clinically healthy cows. According to these results, we can suggest that the hepcidin can be used as a marker for the diagnosis of the diseases as an acute phase protein.
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