Keçilerin Enzootik Intranazal Tümörlerinde Telomeraz Enziminin Düzeyinin Belirlenmesi

Abstract

Enzootic intranasal adenocarcinoma (ENA) of goats are contagious tumoral disease that characterized occurrence of tumoral masses in nasal cavity of the animals. The etiological agent of the disease is retrovirus and the disease cause high economical loses in goat industry. Retroviruses, respectively inducing lung or nasal adenocarcinomas. The true economic impact of ENA is not known because affected animals are given insights from the herd before actual diagnosis, and suspected disease incidence is rarely reported. Telomerase regulates the proliferative capacity of cells and this enzyme has critical role in tumor progression. The aim of this study is to evaluate telomerase activity in serum and tumoral tissue in goat with ENA. For this aim 11 goat's serum were analyses for telomerase activity. Tumoral tissue sections of totally 14 death goats were examined by immunohistochemically for telomerase expression. In addition, 10 normal goat's serum and nasal tissues that belong slaughtered healthy animals used as control. This study showed that increased serum and tissue telomerase activity in goats with ENA comparing to controls. Also our results showed that telomerase activity becomes a useful prediction marker for tumor development in infected but clinically healthy goats in infected flocks.