ABSTRACT:In the present study, thirty patients in the age range of 22 to 63 years of age were included after being diagnosed to be having brain tumour on CT scan or conventional MRI. In addition DWI, MRS, and PWI were carried out in these patients. All the patients with suspicious malignant lesions were then subjected to FDG-PET examination. Histopathological correlation was obtained in all the patients to serve as gold standard against which other modalities will be assessed for their sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy. Out of thirty patients selected for this study, twenty cases were found to be malignant and ten cases were benign on Histopathological evaluation. Majority of malignant lesions were glioblastoma multiforme. Amongst benign cases, majorities were meningioma, one was a Granulomatous lesion and one was a benign cystic lesion. MRI including the novel techniques showed high sensitivity and specificity in identifying malignant brain lesions and has a future role in better characterization of brain tumours. Wherever available, it should be integrated in routine workup of patients presenting with brain tumours or for follow up of patients undergone surgery / adjuvant chemotherapy.
This study was conducted on thirty patients of brain tumors diagnosed on CT scan/ Conventional MRI. It was performed in the Department of Radiological and PET Imaging, Institute of Nuclear Medicine and Allied Sciences (INMAS), Brig S. K. Mazumdar Marg , Lucknow road, Delhi. Out of thirty patients, 19 patients (63.33%) were male and 11 patients (36.66%) were female. Their ages ranged from 22 to 63 years. The most common presenting symptom was headache followed by seizures. MRI is a powerful tool for evaluation and characterization of brain tumors because of its superior soft tissue contrast and multiplanar capabilities. All these patients underwent routine MRI sequences, including T1W, T2WI and FLAIR sequences. Histopathological correlation was obtained in all the patients to serve as the gold standard. Out of thirty patients selected for this study, twenty cases were found to be malignant and ten cases were benign on histopathological evaluation. Majority of malignant lesions were glioblastomamultiforme. Amongst benign cases, majorities were meningioma, one was a granulomatous lesion and one was a benign cystic lesion. On conventional MRI sequences, including T1, T2 and FLAIR, there was significant overlap between appearances of benign and malignant lesions in their intensity on various sequences. Moreover, it has got no prognostic value in follow up of patients after therapy.
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