Highlights: A genetic variable has been identified as an atrial fibrillation risk factor Rs2200733 is a type of SNP that increases atrial fibrillation risk, whereas rs3853445, rs6838973, and rs17570669 have the reverse effect Abstract: Atrial fibrillation (AF) is a highly prevalent arrhythmia. The involvement of molecular mechanisms in increased AF risk remains uncertain. However, the paired-like homeodomain transcription factor 2 or pituitary homeobox 2 (PITX2) gene has been linked to AF development. A comprehensive search was carried out to identify all eligible case-control studies in order to assess the association between five single-nucleotide polymorphisms (SNPs) in the PITX2 gene and the risk of AF. This meta-analysis employed the Review Manager (RevMan) software version 5.3 (Cochrane). There were 13 clinical studies, with a total of 11,961 subjects, that met the inclusion criteria. These subjects consisted of 4,440 patients with AF and 7,521 controls. The meta-analysis of five SNP types in the PITX2 gene was done using crude odds ratios (ORs). This revealed that rs2200733 increased the risk of AF (OR=1.80; 95% CI=1.53-2.11; p=0.0005; I2=80%). On the other hand, the other three SNPs decreased the risk of AF, namely, rs385344 (OR=0.75; 95% CI=0.59-0.95; p=0.002; I2=85%), rs6838973 (OR=0.64; 95% CI=0.51-0.81; p=0.0001; I2=73%), and rs17570669 (OR=0.80; 95% CI=0.65-0.98; p=0.03; I2=70%). However, there was no significant association between rs10033464 and AF (OR=1.21; 95% CI=0.97-1.50; p=0.13; I2=83%). In conclusion, depending on the type, SNPs in the PITX2 gene correlate with AF risk factors, either by alleviating or reducing the risk.
Background: As one of the leading causes of vascular morbidity and mortality, peripheral arterial disease (PAD) remains one of the most underdiagnosed and undertreated atherosclerotic diseases. The relatively high prevalence of PAD combined with an aging population, increasing burden of chronic diseases, and poor control of risk factors will contribute to poorer clinical outcomes in the coming decades.Objective: This study aims to identify the clinical profile of PAD inpatients at Dr. Soetomo General Hospital Surabaya in 2019 -2021. Material and methods:This study is a retrospective observational descriptive study using the total sampling technique to acquire data from patients' medical records and arteriography reports diagnosed as PAD, which confirmed by arteriography examination at Dr. Soetomo General Hospital Surabaya during January 2019 -July 2021. Results: Among 74 PAD inpatients included, PAD was more prevalent in men (52.7%) than in women. The most commonly affected age group above the age of 45. Duplex ultrasonography examination reported triphasic waveform was the most commonly found waveform on the left (33.8%) and right (39.2%) lower extremities with the left common femoral artery (55.4%) and right common femoral artery (52.7%) lower as the disease location. Arteriography examination reported complete total occlusion on the left (44.6%) and right (41.9%) lower extremities with femoral artery (51.4%) as the disease location. Critical limb ischemia (70.3%) was the most found clinical presentation among the patients. Antiplatelet agents (93.2%) were the most prescribed pharmacological agent among the patients with PAD. Patients with PAD on average were hospitalized for 6.76 days. Conclusion:This study discovered that the vast majority PAD inpatients were men over the age of 45, with the femoral artery being the most common location for PAD lesion.
Background: Deep Vein Thrombosis refers to a disease where abnormal blood clot is formed within a vein. It is one of the most common vascular diseases with unspecific symptoms and may complicates to pulmonary emboli and cause death. Hence, it is a disease with high morbidity and mortality.Objective: This study aims to identify the characteristics of outpatients with DVT at RSUD Dr. Soetomo during 2019-2021. Material and Methods: This study is a retrospective descriptive study using the total sampling technique to collect samples from patient medical records diagnosed as DVT, which confirmed by ultrasonography examination at RSUD Dr. Soetomo during January 2019 -July 2021.Results: This study discovered 24 outpatients with DVT at RSUD Dr. Soetomo during January 2019 -July 2021. DVT was found to affect more women than men. The most common age group for DVT is 46-55 years old. The most frequently found clinical manifestations were swelling. The vital signs examination results were within normal limits, with the exception of systolic blood pressure, which was found to be higher than normal. The CBC examination results were also within normal limits. DVT was most commonly found in the femoral vein. All of the patient received rivaroxaban as anticoagulant treatment. Conclusion:This study discovered that DVT patients were mostly women and highly found in patients over the age of 40 years with the femoral vein being the most common location of DVT.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.