Background Coronary heart disease is a deadly disease for both men and women. Risk factors for coronary heart disease include age, sex, hypertension, diabetes mellitus, dyslipidemia. The incidence of coronary heart disease is not uniform thus here we reported the profile of coronary heart disease patients in Soetomo General Hospital Objective To analyze the profile of coronary heart disease patients in RSUD dr. Soetomo from February 2018 until September 2018. Materials and Methods A descriptive research based on the medical records patients was done Result There are 65 male patients (76%) and 20 female patients (24%). There are 58% patients aged 50-60 years (49 people), 24% patients aged more than 60 years old (21 people) and 18% patients less than 50 years old (15 people). Types of patients' occupations include 42% public servants (36 people), 36% private employees (31 people), 9% housewives (8 people), 5% retirees (3 people), 3% entrepreneurs (2 people), 1% teachers (1 person), 1% drivers (1 person) , 1% fishermen (1 person), 1% pastor (1 person) 1% merchant (1 person). The main complaints of patients included chest pain (40% or 34 cases), shortness of breath (23.5% or 20 cases),PCI pro staging therapy (4.6% or 4 cases), thump chest (1.2% or 1 case), lower right abdominal pain (1.2% or 1 case), right leg pain (1.2% or 1 case), nausea (1.2% or 1 case), vomiting (1.2% or 1 case), cough (1.2% or 1 case), dysentery (1.2% or 1 case) and no complaints (23.5% or 20 cases). Inpatients with coronary heart disease in Dr. Soetomo General Hospital have a history of hypertension (30.6% or 38 people), heart disease (22.6% or 28 people), diabetes mellitus (21.9% or 26 people), smoking (5.6% or 7 people), dyslipidemia (3.2% or 4 people), stroke (2.4% or 3 people) ), pulmonary TB (0.8% or 1 person), COPD (0.8% or 1 person) and no history of disease (12.9% or 16 people). Fifty-two patients had blood sugar levels of ≥100 mg / dl with a data percentage of 61%. While 16 other patients had blood sugar levels <100 mg / dl with a data percentage of 19%. And the remaining 17 patients did not get data with a percentage of 20% Conclusion We found 85 patients, predominantly males of 50-60 age group. The commonest occupation of these patients is public servant, and they came with major complaints of chest pain with past history of hypertension and high blood levels.

Background The cases of Rifampicin-Resistant Tuberculosis (RR-TB) in our country have increased every year and RR-TB deaths are thought to be caused by prolongation of the QTc interval due to side effects of anti-tuberculosis drugs. Thus, cytokines are needed to be used as early markers of prolongation of the QTc interval in RR-TB patients. Objective This study aims to analyze the correlation of inflammatory cytokines on QTc interval in RR-TB patients who received shorter regimens. Methods This study uses a case-control study with a time series conducted in the period September 2019 to February 2020 in one of the referral hospitals for Tuberculosis in Indonesia. Cytokines levels from blood samples were measured using the ELISA method, while QTc intervals were automatically recorded using an electrocardiography machine. The statistical analysis used was the Chi-square test, Man Whitney test, Independence t -test, and Spearman-rank test with p < 0.05. Results There was no significant correlation between inflammatory cytokines and QTc prolongation in intensive phase which TNF-α value (6.8 pg/ml; r = 0.207; p = 0.281), IL-1β (20.13 pg/ml; r = 0.128; p = 0.509), and IL-6 (43.17 pg/ml; r = −0.028; p = 0.886). Meanwhile, in the continuation phase, the values for TNF-α (4.79 pg/ml; r = 0.046; p = 0.865), IL-1β (7.42 pg/ml; r = −0.223; p = 0.406), and IL- 6 (40.61 pg/ml; r = −0.147; p = 0.586). Conclusion inflammatory cytokines (TNF-α, IL-1β, and IL-6) cannot be used to identify QTc interval prolongation in RR-TB patients who received shorter regimens.

Background long-term use of anti-tuberculosis drugs (ATD) increases the risk of QTc prolongation, while C-reactive protein (CRP) can be used as an inflammatory marker of Mycobacterium tuberculosis infection. Objective: correlation of CRP on the QTc interval in Rifampicin-resistant tuberculosis (RR-TB) patients with the short regimen. Methods An observational study was conducted in Rifampicin-resistant tuberculosis (RR-TB) patients from 2 groups, patients on intensive phase and patients on continuation phase. CRP levels were measured from blood samples and measured automatically using the immunoturbidimetric assay. QTc interval was calculated using electrocardiography. Levels of CRP levels and QTc interval between the 2 groups were analyzed. The statistical analysis used includes the independent t -test, Mann Whitney test, and Rank Spearman test with p = 0.05. Results Forty-five eligible RR-TB patients were included in this study. CRP levels and QTc intervals between 2 groups (intensive and continuation phase) showed significant difference with p < 0.001 but found no significant correlation of CRP levels and QTc interval in both intensive and continuation phase with p = 0.226 and 0.805, respectively. A higher level of CRP strongly indicated the inflammation caused by RR-TB infection at the early phase of the disease, but not correlated with QTc interval in RR-TB patients. Conclusion Levels of CRP and QTc interval do not correlate in RR-TB patients and can not be used to be the marker of QTc prolongation in RR-TB Patients.

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Determining management strategies in an individual with intermediate cardiovascular risk represent a great challenge. The impact of increased CIMT to improve estimated cardiovascular disease (CVD) risk score in individual at intermediate cardiovascular risk has not yet been fully elucidated. For this reason, we sought to determine the association between CIMT increment and incident of CVD. We conducted a longitudional retrospective cohort study involving 28 patients with intermediate cardiovascular risk (Framingham risk score 10% - 20%). Subjects with criteria fulfillment had their data collected through history taking, physical examination, and CIMT re-measurement using echocardiography. Bivariate analysis with regression logistic showed significant correlation between increased CIMT with CVD event (p=0.016). CIMT measurement is a plausible noninvasive method to predict subclinical cardiovascular disease to further promote more aggressive management.