One hundred and fifteen patients who were treated by a proctocolectomy in Oxford between 1972 and 1984 for inflammatory bowel disease have been studied. All the patients had the rectum removed by the technique of perimuscular dissection which was introduced in 1972 in an attempt to overcome the problems associated with the previous types of proctectomy. The method has been shown to be safe; the operative mortality was 1.7 per cent. The most worrying potential complications due to permanent autonomic nerve damage (i.e. impotence and urinary incontinence), which previously have been recorded as occurring in a significant percentage of patients, were completely prevented by the method of dissection. One man suffered transient impotence which responded to psychiatric treatment. There were no long term urinary tract or sexual problems. Postoperative complications occurred in 37 per cent of patients, perineal wound infections being the most common (25.7 per cent). Perineal healing, however, was achieved in 75 per cent of patients by the time of their discharge from hospital. The mean length of postoperative hospital stay was 19 days in patients with ulcerative colitis and 15 days in patients with Crohn's disease. Our rate of perineal healing is better than has been recorded using other operative techniques.

Western Bahia, part of a large Brazilian agricultural frontier, is located mainly in fragile, sandy soils in a tropical seasonal climate with dry winters, characteristics that facilitate soil carbon loss. This study evaluates whether rainfed and irrigated agriculture in Western Bahia were able to sequester carbon and re-establish the soil organic carbon content (SOCC) lost due to land use change. Between 2010 and 2018, a total of 5469 soil samples were collected in the 0.00–0.20 m soil layer from nine farms and were used to calculate the annual rate of SOCC variation. The most recent SOCC measured in plots where land use change occurred 20 years ago was compared with the SOCC measured in areas of native vegetation (Cerrado). Results showed that (i) irrigated sandy agricultural lands replenished SOCC to the level observed in native vegetation by 20 years after a land use change event and are still capturing carbon at a significant rate, (ii) clayey, rainfed agricultural lands also sequester carbon, but these soils are not representative of the region, and (iii) sandy, rainfed agricultural lands, the predominant soil type and management practice in Western Bahia, are not a sink of CO2.

Modeling ERP software means capturing the information necessary for supporting enterprise management. This modeling process goes down through different abstraction layers, from enterprise modeling to code generation. Thus ERP is the kind of system where enterprise engineering undoubtedly has, or should have, a strong influence. For the case of Free/Open Source ERP, the lack of proper modeling methods and tools can jeopardize the advantage brought by source code availability. Therefore, the aim of this paper is to present a development process proposal for the Open Source ERP5 system. The proposed development process aims to cover different abstraction levels, taking into account well established standards and common practices, as well as platform issues. Its main goal is to provide an adaptable meta-process to ERP5 adopters.

RESUMOAmostras de sangue de animais infectados com cepa Y de Trypanosoma cruzi foram submetidas, respectivamente, a 200 e 300 krad de radiação gama. Para verificar a eficácia do método na eliminação do parasita, o material foi ino¬ culado em camundongos e os parâmetros utilizados na avaliação foram: para¬ sitemia, cultura, xenodiagnóstico, subinoculação, reinoculação com cepa virulenta e exame anátomo-patológico das vísceras. Os sangues expostos às duas diferentes intensidades de radiação e inoculados em dois períodos após o processo, mostraram-se inócuos quanto a capacidade de produzir infecção nos animais UNITERMOS: Doença de Chagas -Camundongos -Raios Gama I NTRODUGAO O risco da veiculação de agentes parasitá-rios e infecciosos se constitui num dos problemas da hemoterapia. Em nosso meio, o mecanismo transfusional vem se tornando cada vez mais importante como forma alternativa da transmissão de Doença de Chagas 1041. Serviços de hemoterapia têm utilizado recursos vários visando a prevenção da transferência do agente causai, o flagelado Trypanosoma cruzi, através de sangue e seus derivados ou componentes. Com esta finalidade, a seleção rigorosa dos doadores, através quer de inTerrogatório minucioso quanto a dados epidemioldgicos, quer de realização de testes sorológicos específicos nem sempre é viável ou tem-se mostrado eficaz. Assim que, o emprego de tripanossomicidas adicionados ao sangue passa a representar o recurso recomendado e adotado em circunstâncias especiais. A violeta de genciana a 1/4.000 adicionada ao sangue a ser transfundido é o método classícamente utilizado no nosso país s -9 , constituindo recurso útil e válido na maioria das circunstâncias, a despeito de restrições que possa apresentar principalmente na superdosagem, onde os efeitos tóxicos poderiam estar presentes além da inconveniência de alterar a coloração da pele. Tem sido preocupação dos hematologistas, utilizando métodos bioquí-micos modernos, o dimensionamento de possí-veis ações deletéricas, sobre o eritrócito, ocasionados pela adição de substâncias diversas ao sangue, assim como a avaliação do risco da potencial toxicidade para o receptor. Recentemente, a anfotericina B, antibiótico poliênico, mostrou-se eficiente como tripanossomicida 3 tendo sido estudado o efeito de sua adição sobre o sangue armazenado 1 .Voltados para o uso de agentes físicos, a literatura mostra várias iniciativas W 2 -" visando verificar a ação dos mesmos sobre T. cruzi em especial o uso de radiações atendo-se, todavia, no estudo das alterações na infectividade e na ação patogênica do microrganismo,

Enterprise Resources Planning (ERP)

This study investigated the co-treatment of landfill leachate/domestic wastewater in bench-scale activated sludge (AS) reactors to determine whether the slowly biodegradable organic matter (SBOM) was removed rather than diluted. The AS reactors were loaded with mixtures of raw leachate and leachate that was pretreated by air stripping. The tested volumetric ratios were 0%, 0.2%, 2% and 5%. For all of the tested conditions, the reactors performed better when pretreated leachate was used rather than raw leachate, and the best volumetric ratio was 2%. The following removals were obtained: 97% for the biochemical oxygen demand (BOD5,20), 79% for total suspended solids, 77% for dissolved organic carbon and 84% for soluble chemical oxygen demand. Most of the pretreated leachate SBOM (65%) was removed rather than diluted or adsorbed into the sludge, as confirmed by Fourier transform infrared (FTIR) spectroscopy analyses.

Single doses of praziquantel were administered by oral route, at various time intervals, following the experimental infection of mice with Hymenolepis nana eggs (2000 per animal), to investigate the drug action against different development stages of the parasite. It was shown that either 25 or 50 mg/kg given on the 4th day after inoculation had just a partial effect against the cysticercoids. Moreover, 25 mg/kg given on the 7th day was not able to kill all juvenile forms as well. However, this dose administered on the 10th day, when the parasites had reached maturity taut oviposition was not yet initiated was 100% efficacious. The same degree of efficacy was achieved with the administration of 25 mg/kg on the 14th day when the fully mature worms already lay eggs. These animal findings indicate that in the treatment of human hymenolepiasis praziquantel, 25 mg/kg, should be taken twice, 10 days apart, so that the second dose kills the larval and juvenile forms which have survived the first one. This should be particularly recommended for treating H. nana infection in close communities.

The current study aimed to follow the effects of social/physical distancing strategies on health-related daily physical activity and quality of life among older adults during the COVID-19 pandemic. Seventy-two older adults who were enrolled in a University–Community program in March 2020 (age = 66.8 ± 4.82 years, ♀59) answered five phone-based surveys up to 120 days after the COVID-19 outbreak (from April to August 2020). The Short Form 6D and international physical activity (short version) questionnaires were applied. A significant reduction was observed in daily physical activity levels, metabolic equivalent of task, and health-related quality of life scores as well as an increase in sitting time during the week and on weekend days (all p < .01). The authors noted differences in lifestyle conditions at the beginning of the social/physical distancing in the community assessed (p < .01). Health vulnerabilities among older adults have been emphasized during the COVID-19 outbreak, impacting daily physical activity and health-related quality of life.