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Purpose Children with cerebral palsy (CP) often exhibit difficulties in feeding resulting from deficits in chewing. This study investigates the therapeutic potential of Ltryptophan (TRI) to reduce deficits in chewing in rats subjected to an experimental model of CP. Methods A total of 80 Wistar albino rats were used. Pups were randomly assigned to 4 experimental groups: Control Saline, Control TRI, CP Saline, and CP TRI groups. The experimental model of CP was based on the combination of perinatal anoxia associated with postnatal sensorimotor restriction of the hind limbs. TRI was administered subcutaneously during the lactation period. Anatomical and behavioral parameters were evaluated during maturation, including body weight gain, food intake, chewing movements, relative weight and the distribution of the types of masseter muscle fibers. Results The induction of CP limited body weight gain, decreased food intake and led to impairment in the morphological and functional parameters of chewing. Moreover, for a comparable amount of food ingested, CP TRI animals grew the most. In addition, supplementation with TRI improved the number of chewing movements, and increased the weight and proportion of type IIB fibers of the masseter in rats subjected to CP. Conclusion These results demonstrate that experimental CP impaired the development of mastication and that TRI supplementation increased masticatory Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation maturation in animals subjected to CP.

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Studies have shown that changes in mastication are related to overweight in children and adolescents as these changes influence the increase in food consumption. The objective of this article was to characterize, through a systematic review, the mastication in children and adolescents with overweight or obesity. For this, two independent authors performed a systematic review of the electronic databases: Medical Literature Analysis and Retrieval System Online, Scopus, Cumulative Index to Nursing and Allied Health, Web of Science and Latin American and Caribbean Literature in Health Sciences. Masticatory characteristics were considered as primary outcomes; the methods of analyzing mastication, the physical characteristics of the foods/materials used in the analyses and the fasting time were considered as secondary outcomes. This review was prepared in accordance with the items of the preferential reports for systematic analysis and meta-analysis. The systematic review protocol was submitted to the International Prospective Registry of Systematic Reviews. Nine articles were included in this review. The reviewed articles suggest that children and/or adolescents with overweight or obese present masticatory damages because they have worse masticatory performance and altered orofacial myofunctional characteristics.

Objetivo: identificar a prevalência de síndrome metabólica e seus fatores associados em idosos com diabetes mellitus tipo 2. Métodos: estudo descritivo observacional realizado com idosos diagnosticados com diabetes mellitus tipo 2, no período de 2017-2018, recrutados no Ambulatório de Nutrição/Diabetes do Núcleo de Assistência ao Idoso da Universidade Federal de Pernambuco. Foram coletados os dados: sexo e faixa etária e, para a avaliação antropométrica dos participantes, foram mensurados o índice de massa corporal e a circunferência de cintura. Também foram coletados os valores de colesterol total e frações, além de glicemia em jejum, hemoglobina glicosilada e diagnóstico prévio de hipertensão arterial. Para analisar os dados obtidos foram utilizados os testes t de Student, Qui-quadrado de Pearson e teste de MannWhitney. Para as análises, foi adotado um intervalo de confiança de 95% e nível de significância de 0,05. Resultados: a amostra foi de 273 participantes, com média de idade de 68,77±5,65 anos e cerca de 89,8% (n=158) apresentaram síndrome metabólica. A presença dessa condição foi associada a valores maiores de peso corporal (p=0,04), índice de massa corporal (p=0,003), circunferência de cintura (p<0,001) e glicemia em jejum (p=0,007). Conclusões: ocorreu alta prevalência de síndrome metabólica nos idosos estudados com essa condição associada a valores maiores de peso corporal, índice de massa corporal, circunferência de cintura e glicemia em jejum. Esses achados demonstram a importância na identificação precoce e na intervenção preventiva dessas condições na população idosa, diminuindo a morbimortalidade por ocorrência de eventos cardiovasculares e melhorando sua qualidade de vida.

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Introduction: Viral infections affect oxidative metabolism and may have repercussions on mitochondrial alterations, compromising cellular homeostasis. Objectives: To assess mitochondrial bioenergetics and oxidative balance in in vitro arbovirus infection models. Methods: The review was written in accordance with the PRISMA and submitted to the Open Science FrameWork platform with DOI 10.17605 / OSF.IO / 8ZFSW. Were used the Descriptors/MeSH (Arbovirus, Arboviruses, Arbovirus infections, Mitochondria, Oxidative stress and Reactive oxygen species) was carried out on the platforms: PubMed, SCOPUS, COCHRANE, Lilacs and Web of Science. The quality analysis of the studies was performed using the ARRIVE tool adapted to the CONSORT, followed by the KAPPA concordance test, were used 24 articles. Results: Results show morphological alterations in the mitochondria, such as swelling, fragmentation, and the appearance of membranes. Mitochondrial stretching was more intense in regions close to the convoluted zones, associated with changes in the genes of mitochondrial dynamics. Changes in oxidative stress biomarkers, antioxidant enzymes and ROS production were evident in most articles, except for those that used cells of immunological origin. Conclusion: Changes in mitochondrial bioenergetic can assist the virus in the replication process, however, these changes can result causing damage cell and of oxidative stress.