Multifunctional materials have received considerable attention as they could integrate different functional components in one‐single platform. In this study, novel chitosan/Fe3O4/TiO2@TiO2 nanowire (NW) microspheres having extracellular matrix‐like fibrous surface and photothermal antibacterial property were synthesized through in situ hydrothermal growth of TiO2 NWs on chitosan/Fe3O4/TiO2 microspheres. It is found that the microspheres were spherical in morphology with a diameter of 100–300 µm and exhibited a hierarchical and nanofibrous feature. Their surface was mainly constructed by numerous TiO2 NWs with a diameter of 20– 30nm. In vitro biological evaluation indicates that the chitosan/Fe3O4/TiO2@TiO2 NW microspheres significantly enhanced attachment and proliferation of human umbilical vein endothelial cells compared with chitosan/Fe3O4/TiO2 nanocomposite microspheres due to the presence of nanofibrous surface. Moreover, the microspheres showed photothermal antibacterial property to inhibit the growth of bacteria due to the presence of Fe3O4 component.
In this study, porous hollow hydroxyapatite (HAp) microspheres are prepared using chitosan microspheres as novel sacrificial templates and their microstructure, biocompatibility, and drug delivery properties are evaluated. Scanning electron microscope (SEM) observations show that HAp microspheres are spherical in morphology with a diameter of 100-300 μm and have a porous and core-shell structure. X-ray diffractometer patterns show that HAp microspheres consist of apatite phase. MTT assay indicates that HAp microspheres are biocompatible and have no significant cytotoxicity. SEM observations show that HAp microspheres support attachment and proliferation of osteoblast MC3T3-E1 cells. After being soaked in the solution of tetracycline hydrochloride (TH, model drug), HAp microspheres adsorb TH with an adsorption capacity of 47% to derive TH-loaded HAp microspheres. When exposed to two types of representative bacteria: Escherichia coli and Staphylococcus aureus, TH-loaded HAp microspheres maintain the biological activity of TH to inhibit the growth of bacteria.
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