The medial preoptic area (mPOA) differs between males and females in nearly all species examined to date, including humans. Here, using fiber photometry recordings of Ca2+ transients in freely behaving mice, we show ramping activities in the mPOA that precede and correlate with sexually dimorphic display of male-typical mounting and female-typical pup retrieval. Strikingly, optogenetic stimulation of the mPOA elicits similar display of mounting and pup retrieval in both males and females. Furthermore, by means of recording, ablation, optogenetic activation, and inhibition, we show mPOA neurons expressing estrogen receptor alpha (Esr1) are essential for the sexually biased display of these behaviors. Together, these results underscore the shared layout of the brain that can mediate sex-specific behaviors in both male and female mice and provide an important functional frame to decode neural mechanisms governing sexually dimorphic behaviors in the future.

Highly efficient conductors are strongly desired because they can lead to higher working performance and less energy consumption in their wide range applications. However, the improvements on the electrical conductivities of conventional conductors are limited, such as purification and growing single crystal of metals. Here, by embedding graphene in metals (Cu, Al, and Ag), the trade-off between carrier mobility and carrier density is surmount in graphene, and realize high electron mobility and high electron density simultaneously through elaborate interface design and morphology control. As a result, a maximum electrical conductivity three orders of magnitude higher than the highest on record (more than 3,000 times higher than that of Cu) is obtained in such embedded graphene. As a result, using the graphene as reinforcement, an electrical conductivity as high as ≈117% of the International Annealed Copper Standard and significantly higher than that of Ag is achieved in bulk graphene/Cu composites with an extremely low graphene volume fraction of only 0.008%. The results are of significance when enhancing efficiency and saving energy in electrical and electronic applications of metals, and also of interest for fundamental researches on electron behaviors in graphene.

AGRP (agouti-related neuropeptide) expressing inhibitory neurons sense caloric needs of an animal to coordinate homeostatic feeding. Recent evidence suggests that AGRP neurons also suppress competing actions and motivations to mediate adaptive behavioral selection during starvation. Here, in adult mice of both sexes we show that AGRP neurons form inhibitory synapses onto ϳ30% neurons in the medial preoptic area (mPOA), a region critical for maternal care. Remarkably, optogenetically stimulating AGRP neurons decreases maternal nest-building while minimally affecting pup retrieval, partly recapitulating suppression of maternal behaviors during food restriction. In parallel, optogenetically stimulating AGRP projections to the mPOA or to the paraventricular nucleus of hypothalamus but not to the LHA (lateral hypothalamus area) similarly decreases maternal nest-building. Chemogenetic inhibition of mPOA neurons that express Vgat (vesicular GABA transporter), the population targeted by AGRP terminals, also decreases maternal nest-building. In comparison, chemogenetic inhibition of neurons in the LHA that express vesicular glutamate transporter 2, another hypothalamic neuronal population critical for feeding and innate drives, is ineffective. Importantly, nest-building during low temperature thermal challenge is not affected by optogenetic stimulation of AGRP¡mPOA projections. Finally, via optogenetic activation and inhibition we show that distinctive subsets of mPOA Vgatϩ neurons likely underlie pup retrieval and maternal nest-building. Together, these results show that AGRP neurons can modulate maternal nest-building, in part through direct projections to the mPOA. This study corroborates other recent discoveries and underscores the broad functions that AGRP neurons play in antagonizing rivalry motivations to modulate behavioral outputs during hunger.

Crop residue retention (RR) is a recommended practice in China and globally. However, comprehensive assessment of changes and mechanisms affecting crop production and soil processes with RR and thus identifying systems of sustainable residues management are not widely studied. A national meta‐analysis was conducted to assess changes in 24 indicators (related to soil quality, soil nutrients, crop yield, and environmental impacts) along with their relationships under RR through 4,910 comparisons from 278 publications across China's croplands. Positively, RR significantly increased crop yield (7.8%), soil organic carbon (SOC) pool (12.3% to 36.8%), soil nutrient reserves (1.9% to 15.2%), soil temperature (6.7%), and water contents (5.9%) and improved soil structure when compared with residue removal (P < .05). Negatively, RR may increase soil acidification and significantly increase emissions of greenhouse gases (by 31.7%, 130.9%, and 12.2% for CO2, CH4, and N2O). Nonetheless, the negative effects can be alleviated, and the positive effects can be strengthened by adopting RR in conjunction with appropriate crops, specific farming practices, and avoiding more than 10 years of consecutive use. The results indicated that a higher decomposition of native and newly added organic matters, induced by RR and attendant changes in soil physical properties, could enhance the dynamics of SOC, microbial biomass, soil nutrients, and the final increase in crop yield and greenhouse gases emissions. Thus, the sustainability of RR‐based system could be enhanced by a careful choice and adoption of integrated farming practices. Proper RR management strategies could offer a climate‐smart solution to ensure food security and sustain soil productivity.

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A two-step double-solvent strategy was first used to incorporate Cu(i) sites into MIL-101(Cr), which obviously improves the CO adsorption performance.

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