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Pregnancy and delivery are critical events in women with von Willebrand's disease type 3. Prophylactic treatment for delivery and early postpartum period is recommended. Vaginal delivery is considered safe. However, experience is based on rare case reports. We report the management of two pregnancies and successful deliveries in a woman with von Willebrand's disease type 3.

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The DARPA Grand Challenge (DGC) was an opportunity to test autonomous vehicles in a competitive situation. In addition to intelligent behaviour, the participating vehicles must also exhibit ruggedness and endurance in order to survive the fast ride over rough terrain (.'win with the software -lose with the hardware". The SciAutonics teams decided to use compact and agile vehicles that employ proven mechanical designs v e v suitable for the desert environment. 4-wheel drive ensures robust controllability even in slippeiy ground, and a roll cage protects the vehicle components from damage in case of a collision. The control system relies primarily on a diferential GPS (Sta$re) and a set of inertial sensors for navigating between the given set of waypoints. A sensor suite using infrared laser (LIDAR) and ultrasound sensing provides the capability of obstacle avoidance and path following. This paper shows the components of the vehicle and results @om driving at the DGC.

Understanding the mechanisms by which parallel evolution occurs has the potential to clarify the complex relationship between evolution and development. In this study, we examine the role of development in the repeated reduction of zeugopod elements during mammalian evolution, a functionally important phenomenon enabling locomotor specialization. By completing a morphometric study (incorporating both analyses of variation and phylogenetics) of mammalian limbs, we are able to demonstrate an evolutionary trend toward width reduction in posterior zeugopod elements of the forelimbs and hindlimbs, the ulna and fibula, respectively. We also examine the developmental basis of limb reduction in three test cases, the bat Carollia perspicillata ulna and fibula and the mouse Mus musculus fibula. The most common pattern of reduction, that of reduced element width, was achieved via the same developmental process in both bat and mouse limbs (i.e., by a slower growth rate relative to other skeletal elements), suggesting that the parallel reduction of the posterior zeugopod element within mammals could have occurred primarily by the repeated evolution of the same developmental mechanism. However, our findings also suggest that the developmental mechanisms behind the parallel evolution of other, more taxon-specific characteristics of limb reduction (i.e., element fusion) are not conserved.

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