Background: The complete blood count is one of the most common routine tests. This study aimed to evaluate possible effects of the antioxidant taurine on the complete blood count of whole blood stored at room temperature and at 4°C over three days.Methods: Venous blood samples of 15 healthy males were distributed into two sets of tubes with each set of three tubes containing 50 μL of solutions with zero, 5 g/L, 10 g/L taurine. The tubes were kept at room temperature or at 4°C. Complete blood counts were performed on three successive days. The mean percentage changes [Δ = (mean value – mean baseline value) / mean baseline value x 100] were calculated and compared.Results: Complete blood count parameters exhibited different patterns of behaviour which were affected by the storage temperature, time and taurine concentration. Taurine at room temperature significantly enhanced the stability of: the platelet count over three days (Δ3 at 5 and 10 g/L taurine were 6.18, and 2.53 x 109 cells/L, respectively); the red blood cell count over three days (Δ3 at 5 and 10 g/L taurine were 2.59, and 1.39 x 1012 cells/L, respectively); mean corpuscular haemoglobin over three days (Δ3 at 5 and 10 g/L taurine were,-0.62 and -0.52 fl respectively); and red cell distribution width over two days (Δ2 at 5 and 10 g/L taurine were 1.30% and -0.1%, respectively). No additional stabilizing effects of taurine were reported for the mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, haematocrit and haemoglobin, while it negatively affected the white blood cell stability.Conclusion: Complete blood count parameters exhibited variable stability patterns in respect to temperature, time and taurine concentration.
Background: Corona virus disease is caused by SARS-CoV-2. This pandemic has affected over 200 countries. Most of the patients are asymptomatic. The disease is usually mild but in approximately 14% of patients it worsens to severe respiratory impairment and admission to ICU. Different tests in laboratories have been used to assess severity and prognosis of severely sick Covid-19 patients in addition to clinical and radiological findings. Aim: To study pattern of Hs- CRP, Ferritin and D-Dimers in Covid-19 patients admitted in Mayo Hospital/ KEMU Duration: June 2020 to October, 2020. Methods: It was a descriptive study conducted in Central Diagnostic Laboratory (CDL) of Mayo Hospital/ KEMU, Lahore on 1474 Covid-19 patients. All samples of the Covid-19 patients sent to CDL of Mayo hospital/ KEMU Lahore for D-Dimers, Hs CRP and Ferritin levels were included in the study. The results and other relevant information were recorded on proforma. The collected data was analyzed by SPSS 23.Quantitative variables like age was presented as mean ± SD. Qualitative variables like gender, single, double or triple parameter abnormalities were presented as frequency and percentage. Results: Out of total 1474, 958(65%) samples were of male and 516(35%) were of female patients. Mean age± SD was50.6±4.2 years. The percentage of abnormal Hs CRP, D Dimers and ferritin was 1386(94%), 1312(89%) and 1135(77%) respectively. The mean±SD value for HsCRP, D-Dimers and ferritin was 56.8±16.9mg/L, 4.4±1.5µg/ml FEU and 770±180 ng/ml respectively. The patients having 3, 2 and 1 abnormal parameter were 988(67%), 456(31%) and 29(2%). Conclusion: Males were more affected with Covid-19 as compared to females. HsCRP is the most frequently raised biomarker in Covid-19 patients and both inflammatory (HsCRP and Ferritin) and coagulopathy marker (D Dimers) were raised in severely sick Covid-19 patients. Keywords: D Dimers, Ferritin, Hs CRP, Covid-19 patients.
Objective: To study the frequency of Hepatitis A Virus and Hepatitis E Virus infections in adult patients of acute hepatitis in a Tertiary Care Hospital in Lahore. Methods: All samples received from medical units (indoor and outdoor) of Mayo hospital Lahore from 26 Feb.2019 to 26.Sept.2019, for Hepatitis A & E IgM antibody testing by ELISA were included in the study. The results and other relevant information were recorded on proforma. Results: Out of 690 study subjects, 62% were male and 38% were female. The mean age ± SD was 33.8 + 7.4years. The percentage of HAV or HEV infected cases was 59%,and 41% were not infected with HAV or HEV. The frequency and percentage of Hepatitis AVirus was 62(15%),whereas the frequency and percentage of HEV was 327(80%) and that of co-infection with HAV and HEV was 21(5%). The mean + SD age of Hepatitis AVirus was 35.2 + 5.0,whereas the mean + SD age of Hepatitis E Virus and co-infection with Hepatitis A and Hepatitis E Virus were 31.45 + 2.3 and 22.6 + 6.3 years, respectively. Conclusion: Hepatitis E Virus is the commonest cause of acute hepatitis in our study,followed by hepatitis A Virus and coinfection of HAV and HEV. Key words: Frequency, Hepatitis A infection, Hepatitis E infection, Co- infection Hepatitis A & Hepatitis E.
Background: In Pakistan more than 25 million people are suffering from kidney diseases. Kidney damage can be detected at earlier stage by simple laboratory tests like renal function tests, proteinuria and estimated Glomerular Filtration Rate (GFR). Objective: To assess renal functions and common risk factors of its impairment in a group of general population on world kidney day 2018. Materials and Methods: It is a descriptive study conducted in Central Diagnostic Laboratory, Mayo Hospital/ King Edward Medical University (KEMU), Lahore It was carried out on 158 Healthy subjects without history of renal disease. All collected data was entered and analyzed by using Statistical package for social sciences (SPSS version 20). Results: 85(54%) were males and 73(46%) females. Mean + SD age was 44.3 ±13.9 years. 50(32%) were hypertensive, 30(19%) were hyperglycemic, 28(18%) had proteinuria, 30(19%) had Hyperuricemia and 18(12%) had increased creatinine levels. Mean ± SD glucose, creatinine and uric acid levels were 130± 30, 1.2± 0.7 and 4.5± 1.3 mg/dl respectively. Conclusion: Screening of subjects without renal known disease with diagnosed hypertension, diabetes or hyperuricemia as risk factors for CKD is required. 18 undiagnosed cases of CKD were identified in this survey. Keywords: risk factors, CKD, Renal function test.
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