This work aimed to study the detection and genotyping of rotavirus, enteric adenovirus, and astrovirus in Egyptian hospitalized children below five years old, associated with non-bacterial diarrhea. In total, 119 fecal samples were obtained from the target population, admitted to Abu El-reesh hospital in Cairo, Egypt. Based on the findings, the detection rate of at least one viral infection was 36.7% in children below five years old, whereas, the overall detection rate of rotavirus, adenovirus, and coinfection was 31%, 6.7%, and 0.8%, respectively. No astrovirus infection was observed. Spring was the peak season for rotavirus and enteric adenovirus. The findings showed that higher rates of rotavirus (78%) and enteric adenovirus (100%) were identified in children less than two years of age. The dominant genotypes were G1P [8] (29.7%), G3P [8] (27%), and G1P [4] (18.9%) for rotaviruses and genotype 41 for enteric adenoviruses. Uncommon genotypes G1P [6] and G9P [8] were also detected in five (13.5%) and four (10.8%) samples, respectively. The present findings indicated that the high incidence of rotavirus and adenovirus in children below two years old. Thus, highlighting the necessity of vaccine development to reduce the incidence of acute viral gastroenteritis in Egypt.