The combined application of organic fertilizer with mineral fertilizer increases the yield of sugarcane. It promotes greater residual beneficial effect in relation to the use of each fertilizer in isolation. The organo-mineral fertilizer presents gradual solubilization during the period of development of the crop. Thus, when compared to soluble mineral sources, its agronomic efficiency may be higher. Various types of organic material can be used, such as pig manure, poultry litter, filter cake and sewage sludge, among others. Organic matter is responsible for maintaining and increasing soil porosity to improve water retention and to ensure soil microbial balance. The efficiency in nourishing the sugarcane crops or availing the available nutrients is maximized. The use of biostimulants in world agriculture has achieved significant growth rates in the last decades. Hormone compounds ensure the sustainability of crops. It can be an alternative to improve plant nutrition, support of abiotic and biotic stresses. They act in the activation and potentiation of the metabolism of the cells, give more vigor to the immune system and help to enable the physiological processes in the different stages of development. The emergence and use of new technologies is the way to achieve greater productivity, sustainability and profitability.