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During tlie last several years a program has been in progrcss in tliis laboratory in which various forms of metabolic inhibition are administered to adult, newborn, arid prcgnant aninials, following which they are studied pathologically. The purpose of this study has been threefold: (1) to learn how various tissues, especially parts of the nervous system, differ from one another iiietabolically and how they will therefore respond differeiitly to the agents; (2) to learn in a siniilaw way how embryonic tissues differ aniong thenisclves, and from the adult, and how their metabolism changes during development ; and (3) to correlate specific metabolic vnlnerabilities of these normal tissues to the problems of cancer chemotherapy and abnormal development.I n the course of administering a wide range of forms of metabolic inhibition from anoxia and hypoglycemia to cytochrome oxidase reagents and vitamin analogues to pregnant animals, it was decided to investigate the effects of ionizing radiations on the developing nervous system. This p a r t of the study using radiation as the "metabolic reagent" was