Circulatory Changes in the 13-Lined Ground Squirrel during the Hibernating Cycle

Lyman, Charles P.; O'Brien, Regina C.

doi:10.21236/ad0261757

Cited by 23 publications

(43 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As has been described previously (Lyman and O'Brien, 1960) an increase in heart rate and often a decrease in peripheral resistance are among the first changes observed when the hibernating animal starts the arousal process. Because of the decrease in peripheral resistance, the blood pressure does not necessarily increase at once, but eventually it rises as the heart beats faster.…”

Section: Arousal From Hibernationsupporting

confidence: 52%

“…The slowing of metabolic rate (Lyman, 1958), respiratory rate (Landau, 1956), and particularly heart rate (Lyman, 1958;Lyman and O'Brien, 1960) prior to any detectable decline in body temperature strongly suggests that these vital functions are being repressed by something more than temperature alone.…”

Section: Section 5 Discussionmentioning

confidence: 99%

“…The heart slows to the rates found in deep hibernation while the body temperature is still several degrees above the environmental temperature, yet body temperature continues to decline for four or more hours thereafter (Lyman and O'Brien, 1960). Finally, the body temperature becomes stable two or three degrees above the environmental temperature.…”

Section: In Hibernationmentioning

confidence: 91%

“…The technique for intubation has been given elsewhere (Lyman and O'Brien, 1960). A thin polyethylene tube (PE 10, OD 0.…”

Section: Section 3 Methodsmentioning

confidence: 99%

“…This was followed by a transient increase in heart rate and blood pressure. Though the cardioacceleration which followed a drop in blood pressure has been considered to be a compensatory response (Lyman and O'Brien, 1960), there was no obvious explanation for the increase in heart rate which occurred almost immediately after the infusion of a parasympathomimetic. It seemed possible that this anomalous response might be an indication of an unusual type of circulatory control in the deeply hibernating animal, and for this reason it was examined in some detail.…”

Section: In Hibernationmentioning

confidence: 99%

See 4 more Smart Citations

Autonomic Control of Circulation During the Hibernating Cycle in Ground Squirrels

Lyman¹,

O'Brien²

1963

Self Cite

View full text Add to dashboard Cite

Section: Arousal From Hibernationsupporting

confidence: 52%

Section: Section 5 Discussionmentioning

confidence: 99%

Section: In Hibernationmentioning

confidence: 91%

“…The technique for intubation has been given elsewhere (Lyman and O'Brien, 1960). A thin polyethylene tube (PE 10, OD 0.…”

Section: Section 3 Methodsmentioning

confidence: 99%

Section: In Hibernationmentioning

confidence: 99%

See 3 more Smart Citations

Autonomic Control of Circulation During the Hibernating Cycle in Ground Squirrels

Lyman¹,

O'Brien²

1963

Self Cite

View full text Add to dashboard Cite

Induced Hypothermia is Not "Artificial Hibernation"

Henderson¹

1966

JAMA

View full text Add to dashboard Cite

The bleakness and chill of autumn evenings forewarns of the coming hostile winter season. Instinctively, a vast segment of the animal kingdom, unable to migrate to a more optimum biologic climate, prepares itself for survival. Through a variety of incredible methods, learned by each surviving species during millenniums of wintering experience, they prepare for their "winter sleep." Almost every earthy aspect becomes a dormitory of sleeping creatures. The frozen earth appears barren and quiet though stocked with countless living forms. The life-and-death interspecies warfare of ordinary life temporarily ceases and natural foes slumber at close quarters beneath swamp mud, in the crevices of rocks, under the stiffened heaps of rotting vegetation and in dead wood. The carpenter ants burrow deeply into their microclimate chambers beneath tree bark and long tortuous tunnels deep in the earth become sleeping galleries for innumerable worms.Larger and more highly developed members of the kingdom siesta through the winter maintaining body temperatures just above the ambient levels and dangerously close to freezing margins often sufficient to crystalize their protoplasmic water. Some species, similar to certain human dozers, sleep deeply and neighboring death; others remain little more than drowsy, easily awakened to fit¬ fully, momentarily raise their body temperature a little and grab a snack from stores close at hand, then return to a state of uneasy somnolence. All of this winter transformation occurs in order¬ ly fashion, unceremoniously and without physio¬ logical fuss. It transpires with a smoothly controlled biochemical decrescendo which remains little un¬ derstood but envied and emulated by all who as¬ pire to utilize induced hypothermia clinically. The "Winterschlaf" of the German writers, the "som¬ meil hivernal" of the French, and the "letargo" of the Italians is the idealistic "winter sleep" so calmly accomplished by nature and so much the goal of the foiled clinician.Early Attempts at Induced Hypothermia Since the pioneering laboratory and clinical re¬ searchers of Temple Fay1 in the 1930's, and the early experiences of numerous others immediately following World War II, applying induced hypo¬ thermia mainly to the field of cardiac surgery, a great deal of effort has been applied to the develop¬ ment of techniques for breaking the thermoregulatory barrier in mammals. Although a far cry from resembling the smoothly executed torpidity of na¬ ture, researchers, surmounted by the proudness befitting great accomplishment, flattered their new achievements by such labels as "artificial hiberna¬ tion," "human hibernation," "induced hibernation," "artificial aestivation," etc. With all of the ad¬ vancements made in recent years in the better understanding of the physiology of both natural hibernation and induced-hypothermia, the term "hibernation" and its synonyms continues to be erroneously applied. Over a hundred publications related to human cooling published during the past year were titled in this manner.Any atte...

show abstract

The Bioenergetic Network of Adenosine in Hibernation, Sleep, and Thermoregulation

Drew

Jinka

2012

Adenosine

View full text Add to dashboard Cite

Circulatory Changes in the 13-Lined Ground Squirrel during the Hibernating Cycle

Cited by 23 publications

References 3 publications

Autonomic Control of Circulation During the Hibernating Cycle in Ground Squirrels

Autonomic Control of Circulation During the Hibernating Cycle in Ground Squirrels

Induced Hypothermia is Not "Artificial Hibernation"

The Bioenergetic Network of Adenosine in Hibernation, Sleep, and Thermoregulation

Contact Info

Product

Resources

About