Objective: The aim of this study is to evaluate the effect of rehabilitation program on quality of life& coping Strategies among patients with knee osteoarthritis at Assiut University Hospital. Method: A quasi-experimental design study was used. Aconvenient sample included 50 patients with knee osteoarthritis 30 of them study group and were control group, who presented to the orthopedics outpatient clinic during 6 months. This study was performed at Assiut University Hospital. Tools of data collection included sociodemographic characteristics questionnaire, Coping strategies scale, quality of life scale for chronic disease . Result: The majority of studied and control groups were females with age group 45-65 years old. 62% of the studied group were illiterate , 70% of studied group and 60% of control group were complaining of this disease for more than 5 years. 22% of studied group had hypertension. More than half of the studied and control group were obese. There was statistically significant correlation between quality of life and affective orientation coping strategies among studied and control group before program. After program, there was statistically significant correlation between quality of life and affective orientation coping strategies. Conclusion: There was no statistically significant difference between studied and control group before program in relation to quality of life. However, there was statistically significant correlation between quality of life and affective orientation coping strategies among studied and control group. Recommendations: Nurses and other healthcare professionals can provide the treatment and prevention and make major contributions to the quality of life of people with knee osteoarthritis