A simple and convenient multi-component domino reaction has been described for the synthesis of novel spirofuran-indenoquinoxaline derivatives. Products were obtained by a three-component condensation reaction between ninhydrin, aromatic 1,2-diamines and dialkyl ethynedicarboxylates in the presence of a catalytic amount of triphenylphosphine in CH 2 Cl 2 at ambient temperature in excellent yields. This one-pot process produces biologically and pharmacologically significant heterocycles with the formation of five new bonds (one CC , two C=N and two CO) and two new rings in a single operation.
Theophylline-catalyzed efficient and environmentally benign procedure for the diastereoselective synthesis of trans-1,2-dihydrobenzo[a]furo[2,3-c]phenazines with pyridinium ylide assisted domino reaction in water.
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