Abstract:The title role of malononitrile in the development of Knoevenagel condensation of organic synthesis and their new findings are explored in this review. The active methylene group of malononitriles is very important attacking part in the heterocyclic conversions and also having a great potency towards several microbial and biological systems.
Contents:
The nanoaluminate spinel Ni1‐xCoxAl2O4 (x = 0.0, 0.25, 0.50, 0.75, 1.0) is effectively synthesized through the use of glycine fuel utilizing a sol–gel combustion heating technique. Nanostructured nickel aluminates nonmaterials, cobalt aluminates, and their variable part spinel structures are calcinated by diligent temperature. The effect of Co2+ ions on the NiAl2O4 force network has contributed to a significant role in the modification and evolution of thermal, spectroscopic, structural, morphological, elementary, and then catalytic behaviors of cobalt‐doped nickel aluminates. It is observed that the synthesized aluminum content serves as an effective nanocatalyst for the processing of higher‐yielding organic compounds. Such methods are then checked to be effective for analyzing the premeditated processes that generated the majority of outcomes.
A simple and clean green method was implemented for the preparation of different succinimide derivatives by means of the N-substituted anilines or N-substituted 2-aminopyridines with succinic anhydride with the heating in aqueous medium. The total synthesized 3a-j compounds were evaluated against antibacterial and antifungal species.
The title role of malononitrile in the development of Knoevenagel condensation of organic synthesis and their new findings are explored in this review. The active methylene group of malononitriles is very important attacking part in the heterocyclic conversions and also having a great potency towards several microbial and biological systems.
A simple ecofriendly microwave supported solvent free synthesis of bis-chalcones was carried out by the reaction of di-substituted 4-hydroxy-3-methoxy benzaldehyde with different substituted N-phenylpiperidine-2, 6-diones in presence of neutral corundum. By the same way the novel bis-pyrazoles were developed from bis-chalcones and hydrazine hydrate with neutral corundum. All the derivatives were characterized and screened their antimicrobial potencies.
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