Malononitrile: A Versatile Active Methylene Group

Dhivare, Ravindra S.; Rajput, S. S.

doi:10.18052/www.scipress.com/ilcpa.57.126

Cited by 7 publications

(7 citation statements)

References 51 publications

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“…The afforded cyclic imide treated with various substituted aromatic aldehyde furnished a series of bis-chalcones. A series of bis isoxazole were prepared in good yield by cyclization of bis chalcone with hydroxyl amine hydrochloride in presence neutral alumina under solvent Journal of Advanced Scientific Research, 2022; 13 (5): June-2022 free microwave irradiation. The afforded bis isoxazole were confirmed by IR, 1 H NMR and elemental analysis.…”

Section: Chemistrymentioning

confidence: 99%

“…A series of bis isoxazole were prepared in good yield by cyclization of bis chalcone with hydroxyl amine hydrochloride in presence neutral alumina under solvent Journal of Advanced Scientific Research, 2022; 13 (5): June-2022 free microwave irradiation. The afforded bis isoxazole were confirmed by IR, 1 H NMR and elemental analysis. , δ ppm): 6.38-8.12 (m, 7H, Ar-H and =C-H), 2.53 (S, 3H, -CH 3 ).…”

Section: Chemistrymentioning

confidence: 99%

“…Isoxazole is a promising structural species for drug designing. Isoxazole based heterocycles are potential bioactive molecules and exhibit anti tubercular [1], analgesic [2], antipyretic [2], anti-inflammatory [2,3], anti platelet [4], anti-HIV [4], antagonist activity [4], CNS depressant [5], anti-fungal [6,7], antibacterial [6-8,14-Journal of Advanced Scientific Research, 2022; 13 (5): June-2022 20], anti-oxidant [7], anti-cancer [9,10] activity. Encouraged by the wide range of biological activities of isoxazole heterocyclic compounds, it was determined to synthesize a new series of isoxazole derivatives.…”

Section: Introductionmentioning

confidence: 99%

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Microwave Assisted Solvent Free Synthesis and Evaluation of Antimicrobial and Antioxidant Activities of Some Novel 3, 4-Bis (Substituted Phenyl)-7-(6-Methyl Pyridin-2-Yl)-3, 3a, 3b, 4-Tetrahydro7h-Pyrrolo [2, 3-C : 5,4-C']diisoxazole

Jadhav¹,

Rajput²,

Patel³

et al. 2022

JASR

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Novel heterocyclic compounds were synthesized, characterized and screened for antimicrobial activity and antioxidant activity. This series of novel bis-isoxazole derivatives were synthesized via reaction of bis chalcone of succinimide treated with hydroxyl amine hydrochloride in presence of neutral alumina by microwave assisted solvent free method in good yield. It was observed that microwave assisted method produced a greater yield of products in shorter reaction times. The structures of synthesized compounds were characterized by their spectral analyses (elemental analysis, FTIR, 1H NMR) and the purity of synthesized compounds were confirmed by TLC. All the synthesized compounds were evaluated for antimicrobial activity against gram positive bacteria Staphylococcus aureus (NCIM 2079) and gram negative bacteria Escherichia coli (NCIM 2109) using DMSO solvent and antifungal activity against fungal strain Aspergillus Niger (NCIM 545). Most of the synthesized compounds exhibited a moderate grade of anti-microbial activity. The study concluded that the compound 4c exhibited potent anti-bacterial activity when compared to Chloramphenicol as standard drug while compound 4b, 4c, 5b, 5c, 5e exhibited significant anti-fungal activity when compared to Amphotericin B as standard drug. All the synthesized compounds were screened for their antioxidant activities. Among them, compounds 4a, 4e, 5a, 5b, 5c and 5e showed moderate to good antioxidant activity when compared to ascorbic acid as standard drug.

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Section: Chemistrymentioning

confidence: 99%

Section: Chemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Microwave Assisted Solvent Free Synthesis and Evaluation of Antimicrobial and Antioxidant Activities of Some Novel 3, 4-Bis (Substituted Phenyl)-7-(6-Methyl Pyridin-2-Yl)-3, 3a, 3b, 4-Tetrahydro7h-Pyrrolo [2, 3-C : 5,4-C']diisoxazole

Jadhav¹,

Rajput²,

Patel³

et al. 2022

JASR

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“…2,35,36 This type of imides, also have a variety of biological and pharmaceutical uses such as CNS depressant, analgesic, antitumor, cytostatic, anorexigenic, nerve conduction blocking, antispasmodic, bacteriostatic, muscle relaxant, hypotensive, antibacterial, antifungal and antitubercular. 2,37,38 Chiral succinimides with antifungal activity have shown higher activity than the corresponding racemic mixtures, thus opening new avenues for the development of highly active drugs containing 3-and 3,4-substituted chiral succinimides. Glutarimide derivatives (4) have a hydrophobic nature, which accounts for their antibacterial and antifungal potencies.…”

Section: Figurementioning

confidence: 99%

“…Glutarimide derivatives (4) have a hydrophobic nature, which accounts for their antibacterial and antifungal potencies. 2,40 The antitumoral and analgesic effects, as well as the effect on the CNS have been reported. 2 The glutarimide moiety is present in alkaloids, such as filantimide, julocrotine and streptimidone, among others.…”

Section: Figurementioning

confidence: 99%

Microwave-promoted synthesis of cyclic imides

Perillo¹,

Shmidt²,

Prieto³

et al. 2018

Arkivoc

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Cyclic imides have been extensively investigated because of the wide range of biological activities they exert, as well as due to their importance as synthetic intermediates. Nowadays, focus has been placed on this important class of compounds for their potential new applications, especially in the area of pharmaceutical chemistry. Consequently, the strategies applied for the synthesis of these compounds have attracted considerable attention. Several innovative methodologies have been developed to obtain and functionalize this class of compounds. The use of microwave heating, which is an environmentally harmless strategy, has been making successful inroads in many chemistry areas, such as organic synthesis. Herein we present an update of the microwave-promoted methods for the synthesis of cyclic imides.

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