Aphtarine is a safe, well tolerated and highly effective promising new treatment for healing common mouth ulcers.
Wound-healing properties have been suggested for Alchemilla vulgaris. Since epithelial and myofibroblast cell growth is required for wound healing, the effects of A. vulgaris on cell growth were investigated in Chang liver and Madin Darby Bovine Kidney (MDBK) epithelial cell lines and rat aortic myofibroblast cultures. Putative healing properties were investigated on dorsal circular 8 mm excisional skin lesions in adult male rats. Cell numbers increased with 0.1-1% A. vulgaris, attaining 21.3 +/- 2.1%, 15.5 +/- 2.25% and 10.6 +/- 0.6% in MDBK, myofibroblast and Chang liver cells, respectively (p < 0.005). No morphological changes or cytotoxicity were noted. In rats A. vulgaris (3%)-treated lesions were significantly decreased in diameter by 10.0 +/- 0.7% (p < 0.005) after 2 days of treatment. On day 3 of treatment, the lesion diameter was significantly reduced by 15.9 +/- 1.1% in glycerine vehicle-treated rats compared with distilled water (p < 0.005), whereas that in A. vulgaris-treated rats was reduced further by 23.2 +/- 1.4% (p < 0.005). Glycerine alone significantly reduced the lesion diameter between days 3 and 5 but complete healing occurred a day earlier in A. vulgaris-treated rats. The results demonstrate wound-healing properties of A. vulgaris associated with promitotic activity in epithelial cells and myofibroblasts.
Objective: External hemorrhoids are enlarged, bulging blood vessels in and around the anus and lower rectum. They associate several pathologies such as engorged, edematous and inflamed sinusoids, with numerous proinflammatory cytokines on their surface, requiring a multi-target therapeutic approach. In the absence of any effective treatment, we assessed a newly conceived osmotically active, hypertonic, filmogen solution (Pileseptine-e) directed at attracting hypotonic liquid and helping suppress inflammation. The clinical efficacy and safety of Pileseptine-e on external hemorrhoids was evaluated in this study. Methods: A 2-week treatment + 1-week follow-up, comparative, randomized, double blind, clinical trial with Pileseptine-e (n=37, test product) versus saline spray (n=17, placebo) was performed in patients suffering from external hemorrhoids. Test and placebo products were applied as 3-4 sprays, 3-4 times per day, for 14 consecutive days. Parameters were evaluated employing a 0-4 or 0-10 scoring scale, before treatment (baseline, T0), 2h after 1st treatment, and on Days 2, 3, 8, and 14, with follow-up check on Day 21. Results: The test product induced an instant and strong outward exudation of liquid from inside the edematous hemorrhoids, thereby cleaning their surface, keeping it hydrated, and reducing pain and itching. A strong reduction in the size of hemorrhoids and rectal bleeding was also observed, which improved the quality of life of the patients considerably. The placebo product also provided noticeable symptomatic relief, but without effect on the size of hemorrhoids. No adverse effects were observed in any patient. Conclusion: Reducing edema to allow hemorrhoidal volume to regress, and to normalize the structural physiology of the anal area, is the primary prerequisite to treat external hemorrhoids. Pileseptine-e is an antiedematous, cleaning, hydrating, safe and non-irritant filmogen solution that represents great advancement in the treatment of external hemorrhoids.
Incidence of chronic wounds is constantly rising worldwide, but all currently available treatments are intended either to provide symptomatic relief or to assist cicatrization to some extent, but not to directly stimulate cellular growth. Physiologically, chronic wound healing simply requires cell growth to fill the injured cavity. To grow, our cells need to attach onto a cushion, called extracellular matrix (ECM), secreted by the mother cells and composed of multiple proteins. Recent scientific works prove that the concentration of certain matrix metalloproteinases (MMPs) is extremely high in all chronic wounds and, because of their proteolytic nature, some MMPs completely degrade the ECM, hindering cell attachment and cell growth. The aim of this study was to identify, neutralize, and eliminate these MMPs from the wound surface so as to design an effective treatment for chronic wounds. Methods: Acute and chronic models of human epithelial and fibroblast cells were prepared on a defined ECM cushion in vitro and MMPs were added in the culture medium to identify the MMPs causing ECM disintegration for each cell type. ECM-degrading MMPs were then incubated with selected procyanidin-rich plant extracts (PCDs) and cell growth was reanalyzed. Results: It was observed that: 1) multiple MMPs are involved in cellular matrix destruction; 2) ECM-destroying MMPs are specific with respect to cell type; and 3) specific PCDs may bind and neutralize selected MMPs. Conclusion: Topical application of specific plant PCDs to selectively neutralize ECMdestroying MMPs in acute and chronic wounds represents a novel approach for the treatment of superficial and deep skin wounds.
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