The fabricated biomaterial showed excellent potential to be developed in to a drug loaded contact lens for sustained glaucoma drug delivery with benefits of low drug content and fewer drug induced side effects.
Surface plasmon resonance (SPR) based immunosensor for rapid and sensitive determination of thyroxine (T4), which is one of major thyroid hormones, has been investigated. Here, a mixed self-assembled monolayer (SAM) of poly(ethylene) glycols (PEG) aromatic dialkanethiols was employed for fabricating sensor surface. As a methodology for low-molecular-weight (lmw) compounds, indirect inhibition that assures the detection of lmw analytes was used for sensitive detection of T4. With these methodologies, T4 could be detected down to 1 ppb (ng ml-1) level with the present SAM-based SPR immunosensor.
Low-cost flexible thin-films exhibiting stimuli-responsive properties were fabricated on poly(methyl methacrylate) (PMMA) as the base supporting material. Labeling of this transparent thermoplastic with Congo red diazo dye revealed its simultaneous pH-responsive and temperature-responsive abilities. UV, FT-IR, and film stability studies identified the role of the dye and the polymer in the flexible thin-film stimuli-responsive behavior. This film is promising for future applications.
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