Background: Safety for blood Transfusion begins with healthy donors. A basic part of preventing transfusion transmitted infections (TTIs) is to notify and counsel reactive donors. This study analysed trends in the prevalence of transfusion-transmissible infectious pathogens among blood donors and notify them as well as to assess response rate among them. Donor notification and counselling protect the health of the donor and stop secondary transmission of infectious diseases. Methods: 38707 blood donations were screened for TTIs, namely, HIV, HBV, HCV, and syphilis, Malarial Parasite by serology. ELISA testing for anti-HIV antibody, anti-HCV antibody and HBsAg and RPR test for syphilis, Rapid card test for Malarial Parasite. All reactive donors were retested in duplicate and notified of their status by communicating through telephone. Result: We evaluated 341 (0.88%) cases with reactive screening test results (0.617% HBV, 0.016% HCV, 0.134% HIV, 0.08% syphilis, 0.031% Malaria ). Only 179 donors (52.5%) responded to notification. The response among voluntary donors was better as compared to the replacement donors (54.1 % versus 40.7 %). Only 101 (57.22%) responsive donors followed their first attendance at referral clinic. Conclusion: Our study provides prevalence rate of TTIs among blood donors and importance of proper donor counselling and notification of TTI status to all reactive donors who opt to receive this information.
Introduction Anemia in the older age (e.g., >60 years) is a major health problem in India and many parts of the world since it signifies an underlying disease and is associated with poor clinical outcome like increased morbidity and affects health‐related quality of life. Since symptoms like fatigue or shortness of breath related to anemia could also be attributed to the aging process, anemia is often easily overlooked in the elderly. Aims and objectives Clinico‐hematological patterns and morphological types of anemia in older age (e.g. >60 years) are manifold, hence this study was undertaken to determine them and to know more about associated disorders. Materials and methodology The present study was conducted on a sample size of 1257 patients who were 60 years and above and clinically diagnosed as anemic. Routine haematological investigations including peripheral blood smear examination and complete hemogram were done. Special investigations like bone‐marrow examination and iron studies were done whenever required. Results Males (aged >60 years) were more affected than females (aged >60 years) and patients in the age group of 60–69 years were affected the most. The most common presenting symptom was generalized weakness. The most common morphological type was normocytic normochromic anemia, and chronic diseases were the commonest etiological factors. Conclusion In spite of modern diagnostic advances, geriatric anemias still remain under‐reported and inadequately investigated, necessitating evaluation of even mild anemias. Prompt diagnosis and definite categorization helps in appropriate management of anemias.
Introduction: There are different types of arthritis seen in elderly patients, of which Osteoarthritis (OA) is the most common. Platelet Rich Plasma (PRP), which is derived from blood, contains many growth factors. Platelet count and indices in PRP has association with pain score of OA, further study will prove its significance. Aim: To find the correlation of platelet parameters like platelet count, Mean Platelet Volume (MPV) and Plateletcrit (PCT) with clinical OA improvement score in PRP-treated patients of OA. Materials and Methods: The longitudinal study was done in the Department of Pathology, PDU Civil Hospital, Rajkot, Gujarat, India, from January 2021 to October 2021. Study was conducted on 40 patients, who were administered intra-articular injection of PRP prepared using double spin method. It was injected at the site of maximum pain in the knee joint. Platelet count, MPV and PCT were noted in the pre and post intervention. Patients were followed-up at two months and six months. The data was analysed using Friedman Analysis of Variance (ANOVA) and Pearson’s correlation test. Results: The mean age of patients was 58.57±4.95 years and there were 26 (65%) females and 14 (35%) males. Increase in platelet count, MPV, PCT in PRP prepared by double spin method and improvement in Visual Analog Scale (VAS) (Before8.38±0.63; After-4.28±0.85), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (Before-63.30±4.99; After- 43.67±5.22) and International Knee Documentation Committee (IKDC) (Before-45.04±6.06; After-66.14±5.78) score were found to be statistically significant. Correlation of platelet parameters WOMAC with Platelet count (p-value=0.052, R-value=-0.310), VAS with MPV (p-value=0.005, R-value=0.436) and IKDC with PCT (p-value=0.032, R-value=0.339) were also statistically significant at six months follow-up. Conclusion: Single dose intra-articular injection PRP in OA knee with KL Grade 1 and 2 is valuable, efficient and costeffective treatment to reduce or delay in knee replacement. The study showed the significant correlation of platelet parameters with OA improvement scores.
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