Background and Aims:
This study aims to evaluate the analgesic effect of ultrasound-guided erector spinae plane block (ESPB) in paediatric lower abdominal surgeries.
Methods:
Randomised, prospective trial. Forty patients, aged 2–10 years with the American Society of Anesthesiologists Score of I and II scheduled for elective lower abdominal surgery were included in the study.
Interventions:
Patients were randomised into two groups as control group and ESPB group. Ultrasound-guided erector spinae plane block at L1 vertebral level was performed preoperatively using 0.5 ml/kg 0.25% bupivacaine (max 20 ml) for the patients in ESPB group. Analgesic requirements and time to first analgesic requirement were recorded and Face, Legs, Activity, Cry and Consolability (FLACC) scores for pain were recorded at 0, 1, 2, 3, 6, 12 and 24 h postoperatively.
Results:
Forty patients were included in the final analyses. Significant difference was determined between the groups on post-operative morphine requirement and FLACC scores at 3 h and 6 h postoperatively (
P
< 0.05). Significant difference was also determined in time to first dose of rescue analgesia between the groups (
P
< 0.05).
Conclusions:
This study shows that the ESPB provides adequate post-operative analgesia in paediatric patients undergoing lower abdominal surgery.
To date, organoseleniums are pre-eminent for peroxide decomposing and radical quenching antioxidant activities. On the contrary, here a series of Janus-faced aminophenolic diselenides have been prepared from substituted 2-iodoaniline and...
A series of novel copper(II) phenolate selenoether complexes have been synthesized and structurally characterized for the first time from copper(I)phenanthroline and various substituted ortho-bisphenylselenide-phenol chelating ligands. The synthesized complex exhibit...
Here, an α-selective Csp3–H bond
functionalization
of primary aliphatic alcohols with 1,4-naphthoquinones yielded Csp2
–Csp2
coupled products
driven by blue-LED light under catalyst, metal, base, and reagent-free
conditions. In this transformation, cleavage of three C–H bonds
(two sp3–C-H, one sp2–C–H,
and one O–H) and four new bonds formed, leading to fluorescent
2-acylated-1,4-naphthohydroquinones.
Selenolato-bridged
manganese(I)-based dinuclear metallacycles [{(CO)3Mn(μ-SeC6H5)2Mn(CO)3}(μ-L)]
(1–4) were achieved in a
single-step process by the self-assembly of dimanganese decacarbonyl,
diphenyl diselenide, and flexible ditopic ester-functionalized pyridyl
ligands [1, L = o-phenylene diisonicotinate
(pdi); 2, L = 1,6-hexanediyl di-4-pyridine carboxylate
(hdp); 3, L = 4-pyridine carboxylic acid diethylene glycol
diester (pcadgd); 4, L = 4-pyridine carboxylic acid triethylene
glycol diester (pcatgd)]. Synthesis of a series of selenolato-bridged
dinuclear Mn(I)-based metallacycles was facilitated via oxidative
addition of C6H5Se–SeC6H5 to (CO)5Mn–Mn(CO)5 with simultaneous
coordination of flexible ditopic pyridyl linkers in an orthogonal
fashion. The metallacycles were characterized by IR, UV–vis,
NMR, and electrospray ionization-mass spectroscopic techniques and
elemental analysis. Solid-state structural elucidation of 3 was carried out using single-crystal X-ray diffraction methods.
In addition, anticancer activity studies were carried out for compounds 2–4 with various cancer cell lines. Furthermore, compound 3 was probed to evaluate its potential CO-releasing property
using myoglobin assay.
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