A new flavonol derivative, meliglabrin (1) along with three known flavonols, ternatin (2), meliternatin (3), and 5,4'-dihydroxy-3,7,3'-trimethoxyflavon (4) were isolated from the leaves of Melicope glabra (Blume) T.G. Hartley. Their structures were determined using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1 -4 were evaluated for their cytotoxicity against murine leukemia P-388 cells, compound 4 showed moderate activity.
Two new isoprenylated benzofuran 3-ones, airlanggin A (1) and B (2) along with two known xanthones, ananixanthone (3) and trapezifolixanthone (4) were isolated from the stem bark of Calophyllum soulattri. Structures of all the compounds were elucidated using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1-4 were evaluated for their cytotoxicity against P-388 cells, showing that compound 3 was the most active with IC 0.68 μg/mL and compound 1 showed moderate activity with IC 5.80 μg/mL.
Erythrina orientalis has local name "Dadap". This plant has known producing alkaloids, flavonoids, pterocarpans, stilbenes, and arylbenzofurans which are active compounds.Three prenylated flavonoids, 8prenyl-daidzein (1), alpinumisoflavone (2) and 4'-O-methyl licoflavanone (3) had been isolated from the stem bark of Erythrina Orientalis. The structures were elucidated on the basis of spectroscopic data,which are IR, UV, MS, and NMR 1D (1 H-NMR and 13 C-NMR) and 2D (COSY, HMQC, and HMBC). Compounds 1-3 were evaluated for their antimalaria with ELISA methods, which showed percentage inhibition values of74.46%, 62.06%, and 0% respectively. Based on the inhibition value showed 4'-O-methyl licoflavanone (1) exhibit very high antimalaria activity compared to compounds (2) and (3).
Abstract:The aim of this study was to assess the antimalarial and antioxidant effects of the n-hexane and ethyl acetate extracts together with three isolated isoprenylated coumarins, mammea A/BA(1),mammea A/ AA cyclo D (2) and mesuol (3) from the stem bark of M. borneensis L. The n-hexane and ethyl acetate extracts, as well as compounds 1-3 were evaluated for their antimalarial activity against Plasmodium falciparum strain 3D7 (chloroquine-sensitive) and their antioxidant activity against DPPH radical scavenging. Compound 2 exhibited slightly more active than chloroquine. Compounds 1 and 3 showed very high activity against DPPH radical.
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