Airlanggins A-B, two new isoprenylated benzofuran-3-ones from the stem bark of <i>Calophyllum soulattri</i>

Tanjung, Mulyadi; Rachmadiarti, Fida; Prameswari, Anindita; Agyani, Villa Ultha Wustha; Saputri, Ratih Dewi; Tjahjandarie, Tjitjik Srie; Syah, Yana Maolana

doi:10.1080/14786419.2017.1380027

Cited by 24 publications

(13 citation statements)

References 7 publications

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“…13 A pair of cis-vinylic doublet signals (J = 10.0 Hz) at δH 6.75 (H-4) and 5.53 (H-3) and one methyl signal at δH 1.53 (11-CH 3 and 12-CH 3 ) are proton signals from group 2, 2-dimethylpirano. 14 The singlet signal at δH 3.69 (N-CH 3 ) is a proton signal of N-methyl. The NMR spectral data were identical with those in references, 13 and TLC analysis of subfraction B1F D2H.3 showed an orange spot with a dragendorf reagent (Figure 3).…”

Section: Fractionation and Identification Of Major Compoundmentioning

confidence: 99%

The Alkaloid Fraction from Melicope latifolia Leaves Inhibits Hepatitis C Virus

Susiloningrum¹,

Permanasari²,

Adianti³

et al. 2020

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the treatment need to be considered as important problems. 4,5 In order to circumvent those problems, the development of new antiviral drugs is very much required. Some plants have been reported to have hepatitis C antiviral activity. Plant extracts from Toona sureni, 6 Artocarpus heterophyllus, 7 Ficus fistulosa, 8 Alectron serratus, 9 and Melicope latifolia 4 significantly inhibited HCV activity in vitro. A variety of active phytochemicals such as flavonoids, terpenoids, lignins, sulphides, polyphenolics, coumarins, saponins, furyl, alkaloids, polylines, thiophenes, protein, and peptides have been identified to inhibit various viruses. 10 Melicope latifolia belongs to the Rutaceae family, commonly known in Indonesia as Ki Sampang and is traditionally used to cure fever and abdominal cramps. The tree typically has a height of about 20 m and is commonly found in primary and secondary open forests. M. latifolia plants are distributed in Malaysia, Philippines, Java-Indonesia, Kalimantan-Indonesia and Papua New Guinea. 11 The chemical compounds which were contained in the M. latifolia plant, are flavonoids, alkaloid, coumarins and terpenoids. 10,12 In general, plant species in the Rutaceae family contain the chemical constituent of alkaloid group, including the Melicope genus.

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Section: Fractionation and Identification Of Major Compoundmentioning

confidence: 99%

The Alkaloid Fraction from Melicope latifolia Leaves Inhibits Hepatitis C Virus

Susiloningrum¹,

Permanasari²,

Adianti³

et al. 2020

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“…Senyawa 2,8-diisoprenil-1,3-dihidroksi-6,7dimetoksisanton (1) berwujud minyak berwarna kuning. Spektrum UV senyawa 1 dalam metanol memperlihatkan absorbansi maksimum pada panjang gelombang λ maks (log ε): 244 (4,27); 261 (4,25); 314 (4,09) dan 353 (3,61) nm yang merupakan kromor senyawa golongan santon . Spektrum IR senyawa 1 dalam KBr memperlihatkan pita serapan pada bilangan gelombang ῡ (cm -1 ): 3424 (vibrasi ulur OH), 1643 (vibrasi ulur C=O terkonyugasi), 1600-1429 (vibrasi ulur C=C aromatik), dan 1211 (vibrasi ulur C-O-C eter).…”

Section: Hasil Dan Pembahasanunclassified

“…Fuskasanton C (2) berwujud minyak berwarna kuning. Spektrum UV [λ maks (log ε): 244 (4,50); 261 (4,51); 312 (4,33); 352 (3,80) nm] dan spektrum IR [ῡ(cm -1 ): 3393, 1642, 1597-1425, 1115] senyawa 2 memperlihatkan kemiripan dengan senyawa 1. Analisis spektrum 1 H NMR (Tabel-2) senyawa 2 dalam aseton-d6 terdiri dari dua unit sinyal proton aromatik, dua sinyal proton rantai samping isoprenil, dua sinyal proton hidroksi dan tiga sinyal proton metoksi.…”

Section: No C δ H (Mult J Hz) δ C Hmbcunclassified

Senyawa Santon Terisoprenilasi dari Kulit Batang Cratoxylum arborescens dan Aktivitas Sitotoksiknya Terhadap Sel HeLa

Iffah¹,

Tanjung²,

Tjahtjandarie³

et al. 2020

Chim. Nat. Acta

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Cratoxylum arborescens merupakan salah satu tumbuhan endemik Indonesia dari kelompok famili Hypericaceae. Penelitian ini bertujuan untuk mengisolasi dan menentukan struktur senyawa santon terisoprenilasi yang terdapat pada kulit batang C. arborescens, serta menentukan aktivitas antikanker senyawa santon terisoprenilasi terhadap sel kanker rahim (HeLa). Ekstraksi dan isolasi senyawa santon terisoprenilasi dari kulit batang C. arborescens menggunakan metanol dengan metode maserasi pada suhu kamar. Pemisahan dan pemurnian dilakukan menggunakan kromatografi kolom gravitasi dan kromatografi radial menghasilkan senyawa 2,8-diisoprenil-1,3-dihidroksi-6,7-dimetoksisanton (1) dan fuskasanton C (2). Struktur senyawa santon terisoprenilasi ditetapkan berdasarkan analisis spektroskopi, meliputi UV, IR, 1D dan 2D NMR. Uji aktivitas sitotoksik senyawa 1-2 terhadap sel HeLa memperlihatkan nilai IC 50 sebesar 116 dan 12 µg/mL.

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“…Calophyllum soulattri, also known as Sulatri, is one of the endemic Calophyllum species in Indonesia. Traditionally, aqueous extract of the stem bark or leaf is used to treat inflammation and rheumatic (Tanjung et al, 2018). Besides, ethanol extract of C. soulattri stem bark has strong antioxidant activity with an IC50 value of 6.82 mg/L (Septiana et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

LC-MS/MS and Cytotoxic Activity Analysis of Extract and Fraction of Calophyllum soulattri Stembark

et al. 2021

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Calophyllum soulattri (Sulatri), a plant from Clusiaceae family, has been empirically used as traditional medicine. In the present study, C. soulattri stem bark extract and fractions were evaluated for their toxicity against MCF-7 breast cancer cell. The extract and fraction’s chemical content was analyzed using the combination of liquid chromatography with mass spectrometry (LC-MS/MS). The results showed that methanol extract and n-hexane fractions have strong cytotoxic activity with IC50 values 93.6 and 36 µg/mL, respectively. Meanwhile, as the positive control, ethyl acetate and cisplatin fractions have IC50 values 233 and 16.2 µg/mL, respectively. The LC-MS/MS analysis showed that the extract and fractions contained polyporusterone A, poricoic acid D, polyporusterone F, esulentagenin, and 1-acetyl-3-(methoxy-carbonyl)-β-carboline. Therefore, C. soulattri stem bark extract and fractions have potential activity as an anticancer agent that was able to inhibit MCF-7 breast cancer cell growth.

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Airlanggins A-B, two new isoprenylated benzofuran-3-ones from the stem bark of Calophyllum soulattri

Cited by 24 publications

References 7 publications

The Alkaloid Fraction from Melicope latifolia Leaves Inhibits Hepatitis C Virus

The Alkaloid Fraction from Melicope latifolia Leaves Inhibits Hepatitis C Virus

Senyawa Santon Terisoprenilasi dari Kulit Batang Cratoxylum arborescens dan Aktivitas Sitotoksiknya Terhadap Sel HeLa

LC-MS/MS and Cytotoxic Activity Analysis of Extract and Fraction of Calophyllum soulattri Stembark

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