Background Definitions for stable dose of warfarin varies in the reported
studies. International warfarin pharmacogenetic consortium (IWPC) algorithm was
generated from the data based on these definitions.
Objective In the present study, we primarily evaluated whether any
significant differences exist between the definitions for stable warfarin
dose.
Methods A prospective cross-sectional study in adults receiving warfarin
for at least 3 months was carried out. Stable doses of warfarin as defined in
previous studies were compared with the standard definition. Bland-Altman plots,
Pearson’s correlation and intra-class coefficients (ICC) were used to
assess the correlation, reliability and agreements between the doses.
Results Sixty-four patients were recruited. Twenty definitions were
obtained from the previous studies. We observed that all but one showed very
high or high positive correlations; and either excellent or good ICC. No
significant differences between the doses initiated and predicted by IWPC
algorithm.
Conclusion We observed similar stable doses between the definitions
except for one. Hence, IWPC algorithm may not have any bias associated with
inclusion of any studies with variable definitions for stable warfarin dose.
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