Health-related quality of life in patients receiving oral anti-coagulants: a cross-sectional study

Sridharan, Kannan; Banny, Rashed Al; Qader, Ali Mohamed; Husain, Aysha; Qader, Kawther Mohamed

doi:10.1080/14779072.2020.1760092

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…We have identified that this risk is higher with the elderly. We observed that the elderly on oral anticoagulants had better quality of life and were more likely to be compliant to the prescribed regimen 17 . Variable consumption of vitamin K–rich foods has been observed in the elderly, and more evidence is emerging relating reduced vitamin K intake to bone health and physical decline in this age group 18 .…”

Section: Discussionmentioning

confidence: 79%

Does fasting during Ramadan influence the therapeutic effect of warfarin?

et al. 2020

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Section: Discussionmentioning

confidence: 79%

Does fasting during Ramadan influence the therapeutic effect of warfarin?

et al. 2020

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“…Selanjutnya penelitian yang dilakukan oleh Sridharan et.al pada tahun 2020 di Bahrain terdahap 150 pasien (143 pasien pengguna warfarin, 7 pasien pengguna dabigatran) menggunakan PACT-Q menunjukan bahwa skor rata-rata pada kelompok warfarin sebesar 80,3 (kenyamanan 47,2 ; beban penyakit 8,7 ; kepuasan pengobatan 28,4) sedangkan skor rata-rata pada kelompok dabigatran sebesar 68 (kenyamanan 42,1 ; beban penyakit 7 ; kepuasan 25,9). Berdasarkan penelitian tersebut bahwa pasien yang menggunakan warfarin memiliki kualitas hidup yang baik daripada yang menggunakan dabigatran 23 .…”

Section: Perception Of Anticoagulant Treatment Questionnaire (Pact-q)unclassified

Instrumen Monitoring Pasien Dalam Terapi Warfarin

Fauzy¹,

Sinuraya²,

Putriana³

2020

Maj. Farmasetika

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Warfarin merupakan salah satu obat antikoagulan oral dengan indeks terapi sempit yang biasa digunakan dalam pengobatan penyakit kardiovaskular. Dalam penggunaannya, warfarin memerlukan perhatian lebih karena dapat berinteraksi dengan obat-obatan lain, alkohol serta makanan. Warfarin juga memiliki efek samping seperti perdarahan dan tromboembolisme. Review artikel ini bertujuan untuk mengulas instrumen yang digunakan dalam monitoring penggunaan warfarin pada pasien rawat jalan serta mengetahui aspek penilaian dan monitoring. Pencarian data bersumber dari database PubMed dan google scholar pada rentang waktu tahun 2010 hingga 2020 dengan kata kunci pencarian monitoring, quality of life, patient, warfarin, therapy. 16 studi diidentifikasi dari 129 studi yang ditemukan dalam rentang waktu publikasi 10 tahun terakhir. Hasil penelusuran menunjukan bahwa instrumen yang paling umum digunakan dalam monitoring adalah kuesioner yang bertujuan untuk mengukur tingkat kepuasan, kualitas hidup, dan kepatuhan pasien selama menggunakan warfarin. Instrumen kuesioner yang paling banyak digunakan untuk monitoring pasien dalam terapi warfarin ialah duke anticoagulant satisfaction scale (DASS) dan short form-36 (SF-36) karena kuesioner tersebut memiliki domain spesifik untuk mengukur dampak positif dan negatif, serta kualitas hidup pasien.

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“…Furthermore, the lack of correlation between INR levels and the efficacy of DOACs eliminates the practical need for routine monitoring of coagulation parameters ( Pirlog AM et al, 2019 ). This aspect is particularly important, as it may negatively affect factors that influence patient adherence and control of antithrombotic therapy ( Davis et al, 2005 ; Raparelli et al, 2017 ; Sridharan et al, 2020 ). Frequent doctor appointments for regular checks, such as an INR blood test or therapeutic drug monitoring might be perceived as stressful and time-consuming by some patients.…”

Section: Introductionmentioning

confidence: 99%

Impact of a DSS-supported medication review on the safety of drug therapy and quality of life in patients with antithrombotic therapy

Hassanzadeh,

Hohmann,

Culmsee

2024

Front. Pharmacol.

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Polypharmacy is common among patients with antithrombotic medication, giving rise to concerns about Drug-Related Problems (DRPs). Therefore, these patients would benefit from a Medication Review (MR) along with pharmacist counselling to reduce the risks accompanying polymedication. This prospective study presents a concept for MRs that are applicable in German community pharmacies and can efficiently support pharmacist counselling and improve the safety of drug therapy. As this is a major challenge in everyday pharmacy practice, we used a Decision Support System (DSS) to evaluate its ability to support the process of pharmacist-led MRs. The primary endpoint was the impact of a community pharmacist on the reduction of DRPs. We investigated the impact of the interventions resulting from MRs on patients taking at least one antithrombotic drug as part of their polymedication regimen. Secondary endpoints were the reduction in the number of patients with bleeding risks and the improvement of patients’ Quality of Life (QoL) and therapy adherence. Furthermore, the DSS used in the study was controlled for correct data assessment and plausibility of data. We selected adult patients who were taking no less than three different medications for long-term treatment, at least one of which had to be an antithrombotic drug, and who were customers in one of eight selected pharmacies over a period of 6 months. Data from 87 patients were analyzed with DSS-support. A total of 234 DRPs were identified by the pharmacist (2.7 DRPs per patient). MR reduced DRPs by 43.2% which, resulting to a reduction of 1.2 DRPs per patient. The intervention also led to a significant improvement in the patients’ QoL (assessed via EQ-5D-5L questionnaire; p < 0.001) and enhanced therapy adherence (assessed via A14 questionnaire; p < 0.001). The control of correct data assessment (with 93.8% concordance) and plausibility of data (with 91.7% concordance) of the DSS software were conducted by an external auditor. No significant effect was found for overall bleeding risk. The results of this study indicate that DSS-supported and structured MR conducted by pharmacists can contribute to a reduction in DRPs and significantly improve patient’s QoL and adherence to treatment.

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Health-related quality of life in patients receiving oral anti-coagulants: a cross-sectional study

Cited by 5 publications

References 27 publications

Does fasting during Ramadan influence the therapeutic effect of warfarin?

Does fasting during Ramadan influence the therapeutic effect of warfarin?

Instrumen Monitoring Pasien Dalam Terapi Warfarin

Impact of a DSS-supported medication review on the safety of drug therapy and quality of life in patients with antithrombotic therapy

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