The two-electron electrochemical oxidation of dopamine is studied voltammetrically at Gold macroelectrodes around neutral pH with simulations used to give kinetic and mechanistic data.
This study demonstrates a fast and simple method to fabricate enhanced ePADs using pencil-drawing with a CO2 laser treatment of the carbon surface deposited on paper. The sensor was applied to the detection of furosemide in a synthetic urine sample.
The electrochemical behavior of heme-phorphyrin iron (III) centered hematin (Htin) was investigated at a Htin modified glassy carbon electrode with cyclic, differential pulse, square wave voltammetry in different pH values. For all pH values, the electrochemical process attributed to the reduction of hematin follows an EE mechanism, in which the ligand suffers mediated electrochemical reduction by the iron metallic center. At the backward scan, the same mechanism is observed for the oxidation of hematin in pH > 5.5. However, the electrochemical oxidation at backward scan in pH < 5.5 occurs firstly and directly at the ligand with the formation of IS (intermediate specie) that is further oxidized at the metallic center and forms Fe(Htin) 3+ . In acid and neutral media, the oxidation of hematin at the positive potential range is an irreversible and pH-dependent process that follows an ECE mechanism. In the first step, the electrochemical oxidation of hematin involves the transfer of one electron from the pyrrolic nitrogen heteroatom with the formation of a cationic radical that loses its iron (III) center in a subsequent chemical step. The resulting cationic radical suffers further oxidation to produce a structure similar to the protoporphyrin IX.
Cyclic Voltammetry at glassy carbon electrode was applied to study the electro-oxidation of Metamizole, a pro-drug largely used in many countries as analgesic which the therapeutic properties are attributed to its hydrolyzed form. Metamizole presents three oxidation processes in aqueous (Britton Robinson Buffer) and DMF media. The first process was characterized as reversible in the last medium. The differentiation between the process associated with the Metamizole and its respective hydrolyzed form the MAA, was investigated and allowed the proposition of a mechanism for the Metamizole electro-oxidation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.