ObjectivesColorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. This study was carried out to see the epidemiological and clinicopathological profile of sporadic cases of CRC in Bangladesh.Materials and methodsThe patients diagnosed to have colorectal carcinoma in two private medical centers of Bangladesh from January 2012 to December 2014 were enrolled in this study. Demographic data, clinical presentations, site of lesions, and histological types were analyzed.ResultsTotal 158 patients were included in this study. The mean age was 50.77 years and male to female ratio was 1.55:1. Rectal bleeding was the commonest symptom irrespective of age and sex followed by abdominal pain (33, 20.9%), weight loss (29, 18.3%), abdominal mass (26, 16.4%), and altered bowel habit (22, 13.9%). Common histological type was adenocarcinoma (156, 98.7%).ConclusionColorectal cancer commonly affects males >40 years of age. Most common site of involvement is rectum, which is followed by left colon.How to cite this articleSaha M, Shil BC, Saha SK, Banik RK, Perveen I, Chowdhury MKS, Nazmul Islam ASM, Saifullah ANM. Study of Clinicopathological Profile of Sporadic Cases of Colorectal Cancer. Euroasian J Hepato-Gastroenterol 2016;6(2):134-136.
Mandibular defects may occur from maxillofacial injury, inflammatory disease, benign or malignant tumour resections and osteoradionecrosis. Mastication, speech and facial disfigurement are often severely compromised without reconstruction leading to poor quality of life. The goal of mandibular reconstruction is to restore facial form and function, repair of mandibular continuity and soft tissue reanimation. Implant insertion should be feasible to allow occlusal rehabilitation and if possible the inferior alveolar nerve function should be restored. Mandibular reconstruction principles and techniques have evolved dramatically over the years. Refinements in techniques continue to improve patient quality of life. This paper reviews short history, current techniques and few promising future endevours related to mandibular reconstruction. Update Dent. Coll. j: 2019; 9 (2): 50-54
Since its introduction in early 1990s, endoscopic ultrasound (EUS) has become integral to the diagnosis and staging of various luminal, extraluminal gastrointestinal (GI) and certain non-GI lesions. There is no data on EUS experience in Bangladesh. The aim of this paper is to evaluate the initial recent experience and clinical impact of EUS. All EUS procedures data were recorded prospectively from July 2013 to December 2014. These included patients' demographics, referral details, provisional diagnosis, management plan before and after EUS & indications of procedures. EUS-FNA data recorded included details regarding site, number of passes and histological diagnosis. Two hundred & four EUS procedures were carried out over one and half years. Male female ratio was 1.4:1, mean age was 46.4±20 years. Of these procedures 148 (72.5%) were referrals from physicians and 56 (27.5%) were from surgeons. Most common indications were pancreatobiliary pathologies, esophageal & gastric pathologies. Pancreatobiliary lesions (n=165, 80.9%) included patients with (A) Benign pathologies: Microliths in Gall baldder (n=6), Gall stones (n=12), Biliary ascarrisis (n=22), Choledocholithiasis (n=42), Acute Pancreatitis (n=9), Chronic Pancreatitis (n=15), Pancreatic pseudocysts(n=4) (B) Malignant Pathologies : GB Carcinoma(n=4), Cholangiocarcinoma (n=29), Capancreas (n=9 ), Periampullary carcinoma ( n=12).Esophageal lesion was 9.3% (n = 19) of total procedures. Forty seven percent (n=9) of EUS procedures on esophagus were for staging of esophageal malignancy, 10. 5% (n=2) for restaging or recurrence after chemoradiation and 21% (n=4) for submucosal lesions. Fifteen EUS procedures were carried out for gastric lesions, 07 were for staging of gastric carcinoma, 04
Double balloon enteroscopy (DBE) is a newly developed endoscopic modality for diagnosis and treatment of small bowel disorders. The aim of this study was to evaluate the diagnostic and therapeutic impact of DBE in patient with suspected small bowel disease. This was a prospective study. Sixty one double balloon enteroscopy procedures (30 antegrade 31 retrograde) were done in thirty six patients(20M/16F, mean age 40±12.5 range 16-65 years ) at gastroenterology department, Sir Salimullah Medical College, Dhaka between October 2011 and September 2012. Indications for DBE included chronic abdominal pain 14(38.9%), obscure GI bleeding 11(30.56%), Small bowel obstruction 05(13.89%), and chronic diarrhea 06(16.67%). The morphologic findings were ulcerations 13(36.11%), growth 03(8.33%), vascular ectasia 03(8.33%) and polyp 01(2.78%). Therapeutic interventions were performed in one patient only. No serious complications were observed. Diagnostic yields in case of chronic abdominal pain, chronic diarrhea, obscure GI bleeding and small bowel obstruction were 50%, 66%, 63% and 40% respectively. The findings were adenocarcinoma 04(11%), lymphoma 03(8.4%), tuberculosis 03(8.4%), non specific findings 05(13.9%), IPSID 01(2.8%), crohn's disease 01(2.8%), vascular ectasia 03(8.33%) and normal 16(44.44%). DBE is well tolerated, feasible and useful technique for the diagnosis as well as treatment of small intestinal disorders.
Coronavirus disease (COVID-19) caused by 2019 Novel Coronavirus (2019-nCoV) recently emerged from Wuhan, Hubei province, China in December 2019. It showed devastating nature and already involved almost all the territories all over the world. It is a contagious disease and rapid, reliable diagnosis is needed to take measure for decreasing the infection rate. For detection of COVID-19 nasopharyngeal swab, sputum, bronchoalveolar lavage, saliva and other body fluid identified as useful samples. The aim of this review from recent studies is to explore the possibility of salivary analysis to identify COVID-19. Although nasopharyngeal swab is taken for rRT-PCR test as a worldwide accepted method, but it is a technique sensitive procedure needs expert personnel and adequate protection is necessary to avoid contamination. In the contrary, saliva sample can be taken easily by the patient himself at home which is a low-risk procedure and economical. So, in the pandemic of COVID-19, salivary analysis could be a good option for detection. Future study on this might explore the possible diagnostic capability of saliva for different diseases and underlying mechanism to find out the pathway for targeted drug therapies.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 7-11
AimsTo see the prevalence of lactose intolerance (LI) and related symptoms following oral lactose challenge in healthy volunteers.Materials and methodsSymptoms of abdominal pain, nausea, borborygmi, flatulence, and diarrhea were noted for 24 hours and blood glucose was estimated at 0 hour and 30 minutes after 25 gm oral lactose load to healthy volunteers. Failure to rise blood glucose level ≥ 1.1 mmol/l at 30 minutes after lactose intake from fasting level was taken as lactose malabsorption (LM), i.e., LI.ResultsA total of 166 volunteers (123 males, 43 females) with a mean age 34.78 ± 11.45 years participated in this study. Lactose intolerance was found among 85.54% (n = 142, M = 104, F = 38). The main symptoms of LI were diarrhea (n = 83, 58.4.0%), borborygmi (n = 81, 57.04%), abdominal pain (n = 35, 24.65%), and flatulence (n = 27, 19.0%).ConclusionLactose intolerance among healthy adults may be common in Bangladesh. Diarrhea and borborygmi were mostly associated symptoms of LI.How to cite this articleSaha M, Parveen I, Shil BC, Saha SK, Banik RK, Majumder M, Salam MU, Nazmul Islam ASM. Lactose Intolerance and Symptom Pattern of Lactose Intolerance among Healthy Volunteers. Euroasian J Hepato-Gastroenterol 2016;6(1):5-7.
This is a case report of a 57-year old farmer who presented with a 4 months history of dysphagia and weight loss. Upper gastrointestinal endoscopy revealed submucosal swellings with overlying ulcers at mid to lower part of esophagus. Repeated histopathological evaluation of endoscopic esophageal tissue biopsies showed nonspecific findings. Endoscopic ultrasound showed a hypoechoic mass at submucosal layer with periesophageal lymphadenopathy. Endosonogram guided FNA materials depicted caseating granulomas. Patient was managed with anti-tuberculosis therapy. Follow up endosonography after therapy revealed resolution of the growth and the mediastinal lymph node enlargement and patient was symptomatically improved. J Bangladesh Coll Phys Surg 2020; 38(3): 150-154
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