To Critically Assess the effect of oral vitamin D supplements on wound healing in a patient with diabetic foot ulcer and its impact on lipid metabolism. This is a single-Centre prospective randomised, control-controlled study was conducted in Department of Surgery Datta Meghe Medical College, Hingna, Nagpur, in collaboration with Datta Meghe Institute of Medical Sciences (DMIMS) Deemed to be University from June 2019 TO March 2020. A total of sixty patients were included in this study. A randomised grouping was done, group A vitamin d supplements and group B as an x-control group. In the group, A vitamin D levels were significantly increased after 12 weeks of intervention as compared to baseline while in group B, no change was seen after the intervention. There was a significant change in HbA1c level after intervention as group A vs group B. similar results were seen in total cholesterol levels after intervention in group A, and group B. Wound surface area was (29.83±15.02 vs 21.76±11.30, p=0.02) in group A and (25.06±14.02 vs 21.3±13.19, p=0.28) in group B respectively. The level of high-density lipoprotein in the group was significantly lower in level when compared to group A after 12 weeks of intervention. No significant changes were seen in the triglycerides level in group A and group B., A comparison of group A vs group B after 12 weeks of intervention, was done. It revealed that Vitamin D Glycosylated total haemoglobin cholesterol, High-density lipoprotein and Wound surface area, significantly improved. At the same time, there was no change seen in triglycerides levels in both the group.After intervention with vitamin D supplements for 12 weeks among patients with diabetic foot ulcer had a good result and beneficial effect on glucose metabolism, vitamin D levels, lipid profile and wound healing
To analyze the level of serum Total Cholesterol (Chol), High Density Lipoprotein (HDL), and Triglyceride (TG) in intrauterine growth retardation (IUGR). Methods: For the study comprising total 40 cases for gestational age or Intrauterine Growth restriction babies born in the Department of Obstetrics and Gynecology, CCMMC Durg were selected. A total of 20 age and sex matched healthy subjects taken as control. The circulating levels of Chol, HDL and TG activity were assayed in the serum of control group and in study group. Results: The correlation between serum triglyceride & HDL-Cholesterol concentrations of IUGR group was found to be highly significant with p value < 0.001. This increased triglyceride level & decreased HDL-Cholesterol level in small for date babies signifies onset of coronary heart diseases in later life. The differences in the serum triglyceride concentration were found to be strikingly different in the two groups of newborns. Serum triglyceride in the IUGR group was found to be 101.14 ± 24.69 mg/dl that was significantly higher than that found in AFD control group with an average concentration of 74.33 ± 13.15 mg/dl with a p value < 0.05. Conclusion: The findings that normal variations in fetal size and thinness at birth have implications for health throughout life have prompted a reevaluation of the regulation of fetal development. Impetus has been added to this reevaluation by recent findings showing that a woman's diet and body composition in pregnancy are related to cardiovascular disease risk factors and the prevalence of coronary heart disease in her offspring in adult life. These observations challenge the view that the fetus is little affected by changes in maternal nutrition except in circumstances of famine. If, as we believe, a woman's own fetal growth and diet and body composition before and during pregnancy play a major role in programming the future health of the children, mothers will want to know what they can do to optimize the intrauterine environment they provide for their babies. The complexities of fetal growth and development are, however, such that currently available data form no basis for changing dietary recommendations for pregnant women. The long timescale over which the effects of an adverse intrauterine environment act dictate that we now need to progress beyond epidemiologic associations to greater understanding of the cellular and molecular processes that underlie them.
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