To study the effect of oral vitamin D supplements on wound healing in patient with diabetic foot ulcer and its effect on lipid metabolism

Abstract

To Critically Assess the effect of oral vitamin D supplements on wound healing in a patient with diabetic foot ulcer and its impact on lipid metabolism. This is a single-Centre prospective randomised, control-controlled study was conducted in Department of Surgery Datta Meghe Medical College, Hingna, Nagpur, in collaboration with Datta Meghe Institute of Medical Sciences (DMIMS) Deemed to be University from June 2019 TO March 2020. A total of sixty patients were included in this study. A randomised grouping was done, group A vitamin d supplements and group B as an x-control group. In the group, A vitamin D levels were significantly increased after 12 weeks of intervention as compared to baseline while in group B, no change was seen after the intervention. There was a significant change in HbA1c level after intervention as group A vs group B. similar results were seen in total cholesterol levels after intervention in group A, and group B. Wound surface area was (29.83±15.02 vs 21.76±11.30, p=0.02) in group A and (25.06±14.02 vs 21.3±13.19, p=0.28) in group B respectively. The level of high-density lipoprotein in the group was significantly lower in level when compared to group A after 12 weeks of intervention. No significant changes were seen in the triglycerides level in group A and group B., A comparison of group A vs group B after 12 weeks of intervention, was done. It revealed that Vitamin D Glycosylated total haemoglobin cholesterol, High-density lipoprotein and Wound surface area, significantly improved. At the same time, there was no change seen in triglycerides levels in both the group.After intervention with vitamin D supplements for 12 weeks among patients with diabetic foot ulcer had a good result and beneficial effect on glucose metabolism, vitamin D levels, lipid profile and wound healing

The association between micronutrient levels and diabetic foot ulcer: A systematic review with meta-analysis

“…A total of 37 articles were retrieved after a systematic literature search. Nine were RCTs (13,(16)(17)(18)(19)(20)(21)(22)(23), and 28 were observational studies (15, 24-50) (12 cross-sectional, seven cohort, and nine casecontrol studies).…”

Associations between Nutrients and Foot Ulceration in Diabetes: A Systematic Review

“…Nine studies were randomised controlled trials [17][18][19][20][21][22][23][24][25]. There were two case control studies [26,27].…”

“…Six studies were reported from Iran [17,[19][20][21]24,25] all by the same group. Two studies were carried out in India [12,18], two in the USA [22,28], and one in each of the following; Australia [29], Bahrain [30], Nigeria [26], Saudi Arabia [27], and Sweden [23]. Data are presented as mean ± standard deviation, with decimals rounded to 1 place.…”

“…(i) Six RCTs, all from the same senior author in Iran, included only participants with grade 3 DFU according to the Wagner classification system [17,[19][20][21]24,25]; (ii) One RCT included participants with grade 2-3 DFU [18,23]; (iii) One RCT included participants grade 1-2 DFU [23];…”

“…Four studies report on vitamin D as the primary measure [12,18,19,30]. Another study by Pena et al (2020) also reported on vitamin D deficiency in people with DFU.…”