OBJECTIVES:Ichnocarpus frutescens is a common plant used by tribal people and in Ayurveda for its high medicinal value. The purpose of the study was to investigate whether I. frutescens has any persuasive medicinal property to manage diabetes mellitus.MATERIALS AND METHODS:Initially, male albino Wistar rats were given intraperitoneal injection of streptozotocin-nicotinamide to induce diabetes, followed with the administration of active fraction obtained from the methanolic extract of I. frutescens for the next 28 consecutive days. Glibenclamide (25 mg/kg) was used as positive control.RESULTS:According to the results obtained, active fraction at a dose of 50 mg/kg body weight exhibited significant antihyperglycemic activity, which was evident with reduced blood glucose level up to 58.84%. The active fraction also showed improvement in serum lipid profile as well as regeneration of pancreatic β-cells in diabetic rats. Concurrent histopathological studies reinforce the effect of active fraction in healing pancreas, thus justifying the possible mechanism of its antidiabetic activity.CONCLUSION:The results of the present investigation lead credence to the use of I. frutescens in ameliorating the diabetic condition.
Colorectal cancer, also known as bowel or colon cancer is associated with colon or rectum sections of the intestine. Globally, more than 1 million people are affected by colorectal cancer every year and have been the cause for death in about 715,000 in 2010. As of 2012, it is the second most common cause of cancer in women (9.2% of diagnoses) and the third most common in men (10.0%). It also accounts for the fourth most common cause of cancer death after lung, stomach, and liver cancer. Colorectal cancer develops mostly during aging and as a reason of increasing lifestyle disorders as well as rarely through genetic heredity. Hence, this grows immense interest in the diagnosis, cure, genetic counseling and general awareness about the disease. Surgery, chemotherapy and radiation therapy, either individually or carried out in conjecture, seems to be the best treatment for the disease. Assessment of risk factors is very important in the early detection of the disease. This review aims to compile broadly the available knowledge on the causes of colorectal cancer, the methods for prevention, therapy or treatment of the disease and the guidelines for genetic counseling and general awareness. It also helps in understanding the risk factors in the development of disease.
Objective: The present study was conducted to verify the effect of Caesalpinia bonducella and Cyclea peltata extracts on experimentally induced excision wounds in diabetic rats.Methods: Methanolic and ethyl acetate extract of test sample in PEG base was applied and observed for wound healing effect for a period of 15 d.Results: The data demonstrated statistically significant wound contraction up to 98% in the treated sample as compared to 90% in diabetic control group. The results correlated (r ³ 0.95) with fasting blood glucose level, indicating the deleterious effect of hyperglycemia in wound healing. Histopathological studies indicated moderate granulation with marked epithelial enclose and moderate hyperplasia in groups treated with high dose (100 mg/kg BW) of methanolic extract of aerial part of Cyclea peltata and root of Caesalpinia bonducella. Conclusion: From the study, it can be hypothesized that tested plant extracts favours wound healing in diabetic animals and paves the way for the more detailed study of the phytochemical constituent for therapeutic applications. The present investigation adds to the existing knowledge in the field of therapeutic medicine and may even become the base for the development of herbal based gel formulations or ointments for treating wounds in diabetic patients and thereby continuous usage of synthetic drugs, its associated side effects could be avoided.
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