We noted an earlier age at presentation of malignant tumors. Mature teratoma was found to be the second most common benign tumor (after serous cystadenoma). We also noted a lower percentage of endometrioid tumors. Lower number of stage IV tumors was noted, with a significant number of malignant ovarian tumors presenting at an earlier age.

test with 100% sensitivity and specificity. [1,2] Blood culture has been considered as gold standard for confirmation of diagnosis but these results are available only after 48-72 h. Moreover, in many cases blood culture fails to detect the offending organism/bacteria. So, search is still continuing for a reliable test, especially in culture negative cases. MATERIALS AND METHODSA total of 62 neonates (infant <1 month of age) with clinical suspicion of septicemia were selected in a prospective study over a period of 1 year, from June 2008 to May 2009 in our institute. Septicemia was suspected from clinical history, signs, symptoms, and predisposing factors in mothers and neonates. Maternal factors included illness during pregnancy like hypertension, chronic renal disease, diabetes mellitus, toxemia of pregnancy, antepartum hemorrhage, maternal fever during last 2 weeks of pregnancy, prolonged rupture of membranes (>24 h), meconium stained liquor amnii, and difficult labor with instrumentation. Neonatal factors included artificial resuscitation, intravenous fluid administration umbilical vein catheterization, failure to thrive, refusal to suck, abdominal distension, jaundice, recurrent attacks of apnea and cyanosis, hypothermia, sclerema, and convulsion.Background and objective: Many neonates with sepsis die worldwide due to lack of early diagnosis and prompt treatment. This study was carried out to analyze various immunological and hematological parameters singly and in combination to formulate a guideline for the rapid diagnosis of neonatal sepsis. Materials and Methods:In a prospective study, 62 patients having clinical suspicion of neonatal sepsis were evaluated with a battery of investigations. Neonates admitted for other causes and without clinical suspicion of sepsis were selected as controls (n = 40). The tests included blood culture, hemoglobin (Hb) level, total and differential blood count, absolute neutrophil count (ANC), immature to total neutrophil count (I/T ratio), micro-erythrocyte sedimentation rate (m-ESR), C-reactive protein (CRP), platelet count, serum immunoglobulin M (IgM), and plasma fibrinogen level. Patients were divided into proven cases (positive blood culture) and probable cases (blood culture negative). results: Positive blood culture was seen in 38 cases (61.3%). Raised m-ESR (>8 mm in 1 st h) was seen in 63.2% of proven and 66.7% of probable cases. An I/T ratio of ≥0.2 was seen in 63.2% and 58.3% of proven and probable cases. Morphological changes were detected in 68.4% of proved and 91.7% of probable cases. Positive CRP test (≥6 mg/L) was found in 84.2% of proven and 100% of probable cases. Raised serum IgM, leukopenia, and neutropenia were seen in minority of patients (11-37%). Raised fibrinogen (>400 mg/L) was seen in the patients as well as in controls.conclusions: Four useful tests were m-ESR, I/T ratio, morphological changes in neutrophils, and CRP; and were statistically significant (P < 0.05). Most sensitive test was CRP (84%) and m-ESR was most specific test (94%). Combinatio...